| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
8.B.12.1.1 | The spider toxin Tx2-5 (Matavel et al., 2009). | Eukaryota |
Metazoa, Arthropoda | Tx2-5 of Phoneutria nigriventer (P29424) |
|
8.B.12.1.3 | Hainantoxin XV-2, HnTx-XV-2 of 117 aas. | Eukaryota |
Metazoa, Arthropoda | HnTx-XV-2 of Haplopelma hainanum |
|
8.B.12.1.4 | Cystine knot toxin of 114 aas | Eukaryota |
Metazoa, Arthropoda | Cystine knot toxin of Dolomedes mizhoanus |
|
8.B.12.1.5 | Omega-ctenitoxin-Pn4a (CnTx-Pn4a; neurotoxin Tx3-6; α1-β toxin) of 90 aas and 1 N-terminal TMS. The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. It is a potent blocker of high voltage-activated calcium
channels, acting mainly on P/Q-type (Cav2.1/CACNA1A) calcium channels
and with a minor effect on L- (Cav1/CACNA1) and N-type (Cav2.2/CACNA1B)
calcium channels (Vieira et al. 2005). It blocks glutamate release in synaptic transmission
mediated by calcium channels (Vieira et al. 2003). The toxin also inhibits the KCl-induced
increase of intrasynaptosomal free calcium (Souza et al. 2008). | Eukaryota |
Metazoa, Arthropoda | Toxin of Phoneutria nigriventer (Brazilian armed spider) |
|
8.B.12.1.6 | Spiderine-1a of 166 aas and 1 TMS. It has antimicrobial, insecticidal, cytolytic and cytotoxic activity, and is active against E. coli, E. faecalis, B. subtilis, A. globiformis, P. aeruginosa and S. aureus in submicromolar or low micromolar ranges. It also lyses human erythrocytes and kills HeLA and A549 cells (Vassilevski et al. 2013). | Eukaryota |
Metazoa, Arthropoda | Spiderine of Oxyopes takobius (Lynx spider) (Oxyopes foliiformis) |