| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
8.B.14.1.1 | Sea anemone Class 1 toxin, BgK of 37 aas It blocks channels containing Kv1 subunits; the 3-d structure is known (1BGKA) (Aneiros et al. 1993). See also Kolesova et al. 2023 | Eukaryota |
Metazoa, Cnidaria | Bgk of Bunodosoma granuliferum (Red warty sea anemone) |
|
8.B.14.1.2 | ShK potassium channel toxin (3-d structure known (1BEI; 1C2U_A)) | Eukaryota |
Metazoa, Cnidaria | ShK Toxin of Stoichactis helianthus (P29187) |
|
8.B.14.1.3 | Sea anemone voltage-sensitive K+ channel inhibitor, Actitoxin Aeq1a; of 36 aas. Also bolcks α-dendrotoxin binding (Minagawa et al. 1998). | Eukaryota |
Metazoa, Cnidaria | ShKT of Actina equina Beadlet anemone) |
|
8.B.14.1.4 | Uncharacterized protein of 99 aas. | Eukaryota |
Metazoa, Nematoda | UP of Ascaris suum (Pig roundworm) (Ascaris lumbricoides) |
|
8.B.14.1.5 | ShTK domain protein of 106 aas. | Eukaryota |
Metazoa, Nematoda | ShTK domain protein of Necator americanus (Human hookworm) |
|
8.B.14.1.6 | K+ channel blocker of 74 aas (Jouiaei et al. 2015). Inhibits voltage-gated potassium channels (Kv1.2/KCNA2) and facilitates acetylcholine release at the avian neuromuscular junction. | Eukaryota |
Metazoa, Cnidaria | Toxin of Heteractis magnifica (Magnificent sea anemone) (Radianthus magnifica) |
|
8.B.14.2.1 | Matrix metalloprotease 23 (MMP23), with a C-terminal K channel blocking Toxin Domain, TxD (residues 254 - 290; 37 aas). The NMR structure of the 37 aa toxin domain is available (2K72_A) (Rangaraju et al., 2010). | Eukaryota |
Metazoa, Chordata | MMP23 of Mus musculus (O88676) |
|
8.B.14.2.2 | Matrix metalloproteinase-23, MMP23B, (ADAM23, MMP21 or MMP22) of 390 aas. It regulates the surface expression of several potassium channels by retaining them in the endoplasmic reticulum (Ohnishi et al. 2001; Costa et al. 2015). ADAM22 and ADAM23 have opposite effects on Kv1.1/Kv1.4 currents, ADAM23 inhbiting and ADAM22 activating. The relative expression of these proteins may shape the expression of K+ currents in different neuronal membrane domains (Lancaster et al. 2019).
| Eukaryota |
Metazoa, Chordata | ADAM23 of Homo sapiens |
|
8.B.14.2.3 | Matrix metalloproteinase-14, MMP14 or MT1-MMP, of 582 aas and 2 TMSs at the N- and C-termini. It mediates extracellular matrix (ECM) degradation following targetting and endocytosis into endolysosomes in a flotillin (TC# 8.A.21.3.1)-dependent process. MMP14 promotes cancerous growth and metastasis (Planchon et al. 2018).
| Eukaryota |
Metazoa, Chordata | MMP14 of Homo sapiens |
|
8.B.14.2.4 | Karilysin, Kly, of 472 aas and 1 N-terminal TMS. Karilysin appears to be a major virulence factor of T. forsythia that contributes to evasion of the human immune response and periodontal disease. | Bacteria |
Bacteroidota | Kly of Tannerella forsythia (Bacteroides forsythus) |
|
8.B.14.2.5 | Vitronectin, VTN, of 478 aas. Vitronectin is a cell adhesion and spreading factor found in serum and tissues. It interacts with glycosaminoglycans and proteoglycans. It is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. It is also an inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. It captures and clears soluble precursors of the membrane attack complex (sMAC) (Menny et al. 2021).
| Eukaryota |
Metazoa, Chordata | Vitronectin of Homo sapiens |