TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
8.B.16.1.1









Maurocalcine (MCa) of the scorpion.  The 3-d structure is known (1C6W_A) (Mabrouk et al., 2007).

Eukaryota
Metazoa
Maurocalcin of Maurus palmatus (P60254)
8.B.16.1.2









Egg protein of 92 aas

Eukaryota
Metazoa
Egg protein of Scizosoma japonicum (blood fluke)
8.B.16.1.3









Hadrucalcin of 74 aas. A knottin. Activates both skeletal ryanodine receptors (RYR1) and cardiac ryanodine receptors (RYR2) by inducing a long-lasting subconductance state, rapidly permeating the external membrane of cardiomyocytes and inducing calcium release from intracellular stores. Acts synergistically with caffeine (Schwartz et al. 2009).

Eukaryota
Metazoa
Hadrucalcin of Hadrurus gertschi
8.B.16.1.4









Ω-hexatosin-Hv1e (Ω-Alracotoxin-Hv1e), a knottin of 37 aas.  The 3-d structure of a synthetic construct of similar sequence is availalbe (1HVW_A).

Eukaryota
Metazoa
hexatoxin of Hadronyche versuta or Atrax versutus (funnel web spider)
8.B.16.1.5









Kappa conotoxin sr11aof 32 aas. It inhibits several potassium channels such as Kv1.1, 1.2, 1.3, and 1.6 (Robinson and Norton 2014).

Eukaryota
Metazoa
Conotoxin sr11a of Conus spurius (Alphabet cone)
8.B.16.2.1









Gamma-conotoxin PnVIIA of 80 aas and 1 TMS. It may act on voltage-gated non-specific cation pacemaker channels (HCN). It triggers depolarization and firing of action potential bursts in the caudodorsal neurons of lymnaea. This effect is due to activation or enhancement of a slow inward cation current that may underlie endogenous bursting activity of these neurons (Fainzilber et al. 1998).

Eukaryota
Metazoa
γ-conotoxin of Conus pennaceus (Feathered cone) (Conus episcopus)
8.B.16.2.2









Gamma-conotoxin-like TeA53 of 81 aas.

Eukaryota
Metazoa
γ-conotoxin of Conus textile (Cloth-of-gold cone)
8.B.16.2.3









Contryphan_M_precursor_1 of 63 aa

Eukaryota
Metazoa
Contryphan of Conus marmoreus
8.B.16.3.1









Alpha-conotoxin-like Rt20.2 of 92 aas with 1 N-terminal TMS. Alpha-conotoxins act on postsynaptic membranes,;they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin specifically blocks mammalian neuronal nAChR of the alpha-7/CHRNA7, alpha-3-beta-2/CHRNA3-CHRNB2 and alpha-4-beta-2/CHRNA4-CHRNB2 subtypes.α-conotoxin

Eukaryota
Metazoa
α-Conotoxin of Conus rattus (Rat cone)
8.B.16.3.2









Conotoxin family Q, partial of 64 aas and 1 N-terminal TMS.

Eukaryota
Metazoa
Conotoxing family Q of Conus ermineus (Atlantic fish-hunting cone)
8.B.16.3.3









N-type conotoxin Mr15.2 of 92 aas and 1 TMSs (Dutertre et al. 2013).

Eukaryota
Metazoa
CoTx15.2 of Conus marmoreus
8.B.16.4.1









Iota-conotoxin precursor of 82 aas and 1 N-terminal TMS. Iota contoxin RXIA is 46 aas and activates Nav1.6 and Nav1.2 voltage-gated sodium channels (VGSC).  It contains an inhibitory cystein knot and a D-amino acid.  It contains the cysteine motif:  C-C-CC-CC-C-C as do other members of the family (Robinson and Norton 2014).

Eukaryota
Metazoa
Iota conotoxin of Conus radiatus (Rayed cone)
8.B.16.4.2









Conotoxin ca11a of 80 aas and 1 N-terminal TMS.

Eukaryota
Metazoa
Conotoxin ca11a of Conus caracteristicus (Characteristic cone)
8.B.16.4.3









Teretoxin Tsu15.4 of 77 aas (Gorson et al. 2015).

Eukaryota
Metazoa
Teretoxin of Terebra subulata