TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
8.B.21.1.1









Mu-Cyrtautoxin-As1a or ApsIII insecticidal neurotoxin of 37 aas; an atypical knottin.  Blocks votage-gated Na+ channels in insects (Skinner et al. 1992).  It acts by pluging the outer vestibule of the channel, and also acts in combination with a weak (30%) voltage-independent block of insect voltage-gated calcium (Cav) channels (low-voltage and high-voltage channels). Tested on DUM neurons, it inhibits sodium currents with an IC50 of 540 nM.  The solution structure is available (PDB# 2M36).

Eukaryota
Metazoa
APSIII of Aptostichus schlingeri
8.B.21.1.2









Trantula Jingzhaotoxin-59 (JzTx-59) or Theraphotoxin-Cj1a of 78 aas.  Possibly related to selenoprotein P (SelP) receptor, a knottin protein (TC family 9.B.87).  Fuctions to impair ion channels (Chen et al. 2008).

Eukaryota
Metazoa
JzTx-59 of Chilobrachys guangxiensis
8.B.21.1.3









Nemetoxin-Csp1c or toxic peptide C of 39 aas.  Causes paralysis to insect larvae  such as H.virescens. This knottin toxin of the insecticidal toxin ABC family, is active only on insects.

Eukaryota
Metazoa
Nemetoxin of Calisoga sp.
8.B.21.1.4









Uncharacterized protein of 65 aas

Eukaryota
Viridiplantae
UP of Genlisea aurea
8.B.21.1.5









Putative toxin of 93 aas

Eukaryota
Fungi
Toxin of Colletotrichum orbiculare  (Cucumber anthracnose fungus) (Colletotrichum lagenarium)
8.B.21.1.6









I superfamily conotoxin of 71 aas

Eukaryota
Metazoa
Conotoxin of Conus ebraeus (Hebrew cone)
   
8.B.21.1.7









Putative toxin, CtI-1 of 53 aas

Viruses
Baculoviridae
CtI-1 of Dendrolimus kikuchii nucleopolyhedrovirus
8.B.21.1.8









Kappa conotoxin ViTx of 67 aas and 1 TMS.  Inhibits various potassium channels including Kv1.1, Kv1.2, Kv1.3 and Kv1.6 (Robinson and Norton 2014).

Eukaryota
Metazoa
ViTx of Conus virgo (Virgin cone)
8.B.21.1.9









Kappa conotoxin BTx or BeTx of 70 aas and 1 N-terminal TMS.  It is a modulator of potassium channels, specifically up-modulating the calcium and voltage-gated BK channels. It has no effect on single channel conductance, but increases the open probability of BK channels (Fan et al. 2003).

Eukaryota
Metazoa
BTx conotoxin of Conus betulinus (Beech cone)
8.B.21.1.10









Conotoxin Gla-MrII of 94 aas and 1 TMS.

Eukaryota
Metazoa
Conotoxin Gla-MrII of Conus marmoreus (Marble cone)
8.B.21.2.1









Conotoxin of 76 aas.

Eukaryota
Intramacronucleata
Conotoxin of Tetrahymena thermophila
8.B.21.2.2









Uncharacterized protein of 82 aas and 1 TMS.

Eukaryota
Fungi
UP of Cochliobolus sativus (Common root rot and spot blotch fungus) (Bipolaris sorokiniana)
8.B.21.2.3









Uncharacterized protein of 63 aas and possibly one C-terminal TMS.

UP of Kordia sp.