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8.B.22 The P-Conotoxin Cystine Knot (P-CCK) Family

The P-CCK family of spasmodic conotoxins consists of several toxins.  The structure of a synthetic construct of such a protein has been determined (1IXT; Miles et al. 2002).

This family belongs to the: Conotoxin Superfamily.

References associated with 8.B.22 family:

Miles, L.A., C.Y. Dy, J. Nielsen, K.J. Barnham, M.G. Hinds, B.M. Olivera, G. Bulaj, and R.S. Norton. (2002). Structure of a novel P-superfamily spasmodic conotoxin reveals an inhibitory cystine knot motif. J. Biol. Chem. 277: 43033-43040. 12193600
Pi, C., J. Liu, C. Peng, Y. Liu, X. Jiang, Y. Zhao, S. Tang, L. Wang, M. Dong, S. Chen, and A. Xu. (2006). Diversity and evolution of conotoxins based on gene expression profiling of Conus litteratus. Genomics 88: 809-819. 16908117