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8.B.28.1.4
Mu-conotoxin KIIIA of 18 aas. This toxin potently blocks rNav1.2/SCN2A and rNav1.4/SCN4A but also moderately blocks rNav1.1/SCN1A, rNav1.3/SCN3A, rNav1.5/SCN5A, mNav1.6/SCN8A, and rNav1.7/SCN9A. On rNav1.2/SCN2A, it produces a block that is only partially reversible. The block of SCN9A is modified when beta-subunits are coexpressed with the alpha subunit (McArthur et al. 2011; Zhang et al. 2013). A heterobivalent ligand (mu-conotoxin KIIIA, which occludes the pore of the NaV channels, and an analogue of huwentoxin-IV, a spider-venom peptide that allosterically modulates channel gating (TC#8.B.3.1.3)) slows ligand dissociation and enhances potency (Peschel et al. 2020).  

Accession Number:P0C195
Protein Name:
Length:
Molecular Weight:
Species:Conus kinoshitai
Substrate NONE

Cross database links:

Structure:
2LXG   6J8E     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	CCNCSSKWCR DHSRCCGR