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8.B.4.1.9
Mu (μ)-conotoxin GVIIJ of 82 aas and 1 TMS.  Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin (GVIIJ (SSG)) blocks Nav1.1/SCN1A (Kd=11 nM), Nav1.2/SCN2A (Kd=11 nM), Nav1.3/SCN3A (Kd=15 nM), Nav1.4/SCN4A (Kd=4.7 nM), Nav1.6/SCN8A (Kd=360 nM) and Nav1.7/SCN9A (Kd=41 nM) (Gajewiak et al. 2014; Zhang et al. 2015). Coexpression of subunits beta-2 or beta-4 (but not beta-1 or beta-3) protects rNav1.1-1.7 against block by the toxin (Wilson et al. 2015).

Accession Number:X5IWS1
Protein Name:Mu-conotoxin GVIIJ
Length:82
Molecular Weight:8871.00
Species:Conus geographus (Geography cone) [6491]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate

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Structure:
2N8H     

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FASTA formatted sequence
1:	MKLTCVVIVA ALLLTACQLI TALDCGGTQK HRALRSTIKL SLLRQHRGWC GDPGATCGKL 
61:	RLYCCSGFCD CYTKTCKDKS SA