TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
8.B.41.1.1









Tau-scoloptoxin(04)-Sm1b or RhTx of 69 aas and 1 N-terminal TMS. It is  an extremely potent potentiator of TRPV1 (EC(50) = 521.5 nM). It strongly promotes the heat activation process by downshifting the activation threshold temperature by preferably binding to the activated channel, promoting its opening. Holding the channel closed by cooling prevents binding of this toxin, leaving it ineffective. The toxin binds to the charge-rich outer pore region of the channel where it directly interacts with the pore helix and turret, two adjacent structural elements known to be critical for activation gating of TRPV1. In vivo, it induces pain in mice after intraplantar injection (Lee et al. 2015; Yang et al. 2015). The 3-D structure is known (PD# 2MVA-A). It does not act on mNav1.5/SCN5A, mNav1.7/SCN9A, tetrodotoxin-sensitive and -resistant Nav, mKv1.1/KCNA1, mKv2.1/KCNB1, mKv4.1/KCND1, high voltage activated Cav, low voltage activated Cav, TRPV2, TRPV3 and TRPV4 (Yang et al. 2015).

Eukaryota
Metazoa
RhTx of Scolopendra subspinipes (Vietnamese centipede)
8.B.41.1.2









Kappa-scoloptoxin(04)-Ssd1b of 67 aas and 1 N-terminal TMS.

Eukaryota
Metazoa
κ-Scoloptoxin of Scolopendra dehaani (Thai centipede) (Scolopendra subspinipes dehaani)