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Delta atracotoxin-Hv1a (Versutoxin) (42aas) (NMR structure available (1VTXA)). Antagonist of insect voltage-gated calcium channels (Chong et al., 2007; Khan et al., 2006; Wang et al., 1999) as well as sodium channels (Luch 2010).

Accession Number:P13494
Protein Name:Delta-hexatoxin-Hv1a
Molecular Weight:4856.00
Species:hadronyche versuta (Blue mountains funnel-web spider) [6904]
Location1 / Topology2 / Orientation3: Secreted1
Substrate NONE

Cross database links:

Pfam: PF05353   

Gene Ontology

GO:0005576 C:extracellular region
GO:0019871 F:sodium channel inhibitor activity
GO:0009405 P:pathogenesis

References (9)

[1] “Amino acid sequence of versutoxin, a lethal neurotoxin from the venom of the funnel-web spider Atrax versutus.”  Brown   3355530
[2] “Australian funnel-web spider toxin, versutoxin, enhances spontaneous synaptic activity in single brain neurons in vitro.”  Chieng   8281423
[3] “Modification of sodium channel gating and kinetics by versutoxin from the Australian funnel-web spider Hadronyche versuta.”  Nicholson   7816562
[4] “Selective alteration of sodium channel gating by Australian funnel-web spider toxins.”  Nicholson   9028001
[5] “Delta-atracotoxins from Australian funnel-web spiders compete with scorpion alpha-toxin binding on both rat brain and insect sodium channels.”  Little   9845331
[6] “Electrophysiological analysis of the neurotoxic action of a funnel-web spider toxin, delta-atracotoxin-HV1a, on insect voltage-gated Na+ channels.”  Grolleau   11171353
[7] “Variations in receptor site-3 on rat brain and insect sodium channels highlighted by binding of a funnel-web spider delta-atracotoxin.”  Gilles   11874465
[8] “Phase coupling of a circadian neuropeptide with rest/activity rhythms detected using a membrane-tethered spider toxin.”  Wu   18986214
[9] “The structure of versutoxin (delta-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel.”  Fletcher   9384567

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