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8.B.9.1.2 Natrin toxin, a snake venom cysteine-rich secretory protein that targets various ion channels (e.g., Ca²⁺ activated K⁺ channels, voltage-gated K⁺ channels, and ryanodine receptor Ca²⁺ channels). The 3-d structure is known (Zhou et al., 2008).
Accession Number:	Q7T1K6
Protein Name:	Natrin
Length:	239
Molecular Weight:	26882.00
Species:	Naja atra PE=1 SV=1 [8656]
Location¹ / Topology² / Orientation³:	Secreted¹
Substrate

Structure:
Pfam:	PF08562 PF00188
Gene Ontology GO:0005576 C:extracellular region GO:0019855 F:calcium channel inhibitor activity GO:0019870 F:potassium channel inhibitor activity GO:0009405 P:pathogenesis
References (6) [1] “Purification and cloning of cysteine-rich proteins from Trimeresurus jerdonii and Naja atra venoms.” Jin Y.et.al. 14529736 [2] “Purification and characterization of Taiwan cobra venom proteins with weak toxicity.” Chang L.-S.et.al. 15581679 [3] “Structural and functional analysis of natrin, a venom protein that targets various ion channels.” Wang F.et.al. 17070778 [4] “Structural and functional characterization of ryanodine receptor-natrin toxin interaction.” Zhou Q.et.al. 18658224 [5] “Purification, crystallization and preliminary X-ray crystallographic analysis of a cysteine-rich secretory protein (CRISP) from Naja atra venom.” Wang Y.-L.et.al. 15388950 [6] “Blocking effect and crystal structure of natrin toxin, a cysteine-rich secretory protein from Naja atra venom that targets the BKCa channel.” Wang J.et.al. 16042391
1XTA 1XX5 2GIZ 3MZ8

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MIAFSLLCFA AVLQQSFGNV DFNSESTRRK KKQKEIVDLH NSLRRRVSPT ASNMLKMEWY 
61:	PEAASNAERW ANTCSLNHSP DNLRVLEGIQ CGESIYMSSN ARTWTEIIHL WHDEYKNFVY 
121:	GVGANPPGSV TGHYTQIVWY QTYRAGCAVS YCPSSAWSYF YVCQYCPSGN FQGKTATPYK 
181:	LGPPCGDCPS ACDNGLCTNP CTIYNKLTNC DSLLKQSSCQ DDWIKSNCPA SCFCRNKII

8.B.9.1.2
Natrin toxin, a snake venom cysteine-rich secretory protein that targets various ion channels (e.g., Ca²⁺ activated K⁺ channels, voltage-gated K⁺ channels, and ryanodine receptor Ca²⁺ channels). The 3-d structure is known (Zhou et al., 2008).

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

8.B.9.1.2Natrin toxin, a snake venom cysteine-rich secretory protein that targets various ion channels (e.g., Ca2+ activated K+ channels, voltage-gated K+ channels, and ryanodine receptor Ca2+ channels). The 3-d structure is known (Zhou et al., 2008).

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

8.B.9.1.2
Natrin toxin, a snake venom cysteine-rich secretory protein that targets various ion channels (e.g., Ca²⁺ activated K⁺ channels, voltage-gated K⁺ channels, and ryanodine receptor Ca²⁺ channels). The 3-d structure is known (Zhou et al., 2008).