8.B.9.1.7
Glioma pathogenesis-related protein 1 of 266 aas and 1 C-terminal TMS, GLIP, GLIP1, GliPR, RTVP1, RTVP-1. It influences neutraphil degranulation and regulates lipid metabolism. GLIPR1 is a p53 target gene known to be downregulated in prostate cancer, and increased endogenous GLIPR1 expression has been associated with increased production of reactive oxygen species, increased apoptosis, decreased c-Myc protein levels and increased cell cycle arrest (Karantanos et al. 2014). A deletion mutant, GLIPR1-DeltaTM, is selectively endocytosed by prostate cancer cells, leading to increased reactive oxygen species production and apoptosis (Karantanos et al. 2014).