TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
9.A.1.1.1









The RalA binding protein 1 (RalBP1, RLIP1 or RLIP76) multidrug exporter (Awasthi et al., 2000; Sharma et al., 2001; Awasthi et al., 2007). RLIP76 mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes (Sharma et al. 2001). It can thus catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. The RLIP76 Ral binding domain binds to both the switch regions of RalB, which are the parts of the G protein that change conformation upon nucleotide exchange (Mott and Owen 2010). RLIP76 may play roles in endocytosis, mitochondrial fission, cell spreading and migration, actin dynamics during gastrulation, and Ras-induced tumorigenesis (Goldfinger and Lee 2013). It may additionaqlly serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis (Jullien-Flores et al. 1995).

Eukaryota
Metazoa
RLIP76 of Homo sapiens (Q15311)
9.A.1.1.2









RalA-binding protein 1, isoform X3, of 590 aas and possibly 1 or more TMSs.

Eukaryota
Metazoa
RalA-BP!-X3 of Cephus cinctus (wheat stem sawfly)
9.A.1.1.3









Uncharacterized protein of 985 aas and possibly 1 or 2 TMSs.

Eukaryota
Metazoa
UP of Taenia asiatica
9.A.1.1.4









Beta-chimaerin (β-chimaerin) of 652 aas and possibly 1 or more TMSs.  Residues 450 - 623 align with residuces 183 - 354 in RalBP1 (TC# 9.A.1.1.1).

Eukaryota
Fungi
9.A.1.1.5









Rho GAP domain-containing protein of 1464 aas and possibly 2 TMSs.  The region of homology with RalA-BP1 and β-chimaerin is near the C-terminus of the protein (residues 1119 - 1309).

Eukaryota
Fungi
Rho GAP-like protein of Neurospora crassa
9.A.1.1.6









Uncharacterized protein of 1094 aas and possibly 2 N-terminal TMSs. The region of homolog between this protein and TC# 9.A.1.1.1 is near its N-terminal 150 aas.

Eukaryota
Metazoa
UP of Xenopus tropicalis (tropical clawed frog)
9.A.1.1.7









Active breakpoint cluster region-related protein isoform X8, of 643 aas with a C-terminal region showing homology near the N-terminus of other members of this family.

Eukaryota
Metazoa
Breakpoint cluster protein of Oreochromis niloticus (Nile tilapia)