TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


9.A.14.10.4
Dimeric oxytosin receptor, OxtR, of 389 aas and 7 TMSs. Superpotent behavior follows from the binding of oxytosin receptor-specific bivalent ligands to dimeric receptors based on a TMS1-TMS2 interface, and in this arrangement, only analogues with a well-defined spacer length (approximately 25 Å) precisely fit inside a channel-like passage between the two protomers of the dimer (Busnelli et al. 2016). The oxytocin receptor (OXTR) is involved in parturition and lactation of mammals as well as  their emotional and social behaviors. Cholesterol acts on OXTR as an allosteric modulator, inducing a high-affinity state for orthosteric ligands. Stable binding of cholesterol to the receptor when it adopts an orthosteric ligand-bound state  preserves the cholesterol-dependent activity of the receptor (Lemel et al. 2021).

Accession Number:P30559
Protein Name:Oxytocin receptor
Length:389
Molecular Weight:42772.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Structure:
6TPK     

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MEGALAANWS AEAANASAAP PGAEGNRTAG PPRRNEALAR VEVAVLCLIL LLALSGNACV 
61:	LLALRTTRQK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD ITFRFYGPDL LCRLVKYLQV 
121:	VGMFASTYLL LLMSLDRCLA ICQPLRSLRR RTDRLAVLAT WLGCLVASAP QVHIFSLREV 
181:	ADGVFDCWAV FIQPWGPKAY ITWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA 
241:	AEAPEGAAAG DGGRVALARV SSVKLISKAK IRTVKMTFII VLAFIVCWTP FFFVQMWSVW 
301:	DANAPKEASA FIIVMLLASL NSCCNPWIYM LFTGHLFHEL VQRFLCCSAS YLKGRRLGET 
361:	SASKKSNSSS FVLSHRSSSQ RSCSQPSTA