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Accession Number: | P30556 |
Protein Name: | Type-1 angiotensin II receptor |
Length: | 359 |
Molecular Weight: | 41061.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 7 |
Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
Substrate |
Cross database links:
Entrez Gene ID: | 185 |
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Pfam: | PF00001 |
KEGG: | hsa:185 |
Gene Ontology
GO:0005887
C:integral to plasma membrane
GO:0010698
F:acetyltransferase activator activity
GO:0001596
F:angiotensin type I receptor activity
GO:0004945
F:angiotensin type II receptor activity
GO:0031711
F:bradykinin receptor binding
GO:0046982
F:protein heterodimerization activity
GO:0019722
P:calcium-mediated signaling
GO:0060326
P:cell chemotaxis
GO:0051482
P:elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger
GO:0001822
P:kidney development
GO:0034374
P:low-density lipoprotein particle remodeling
GO:0032270
P:positive regulation of cellular protein metabolic process
GO:0010873
P:positive regulation of cholesterol esterification
GO:0050729
P:positive regulation of inflammatory response
GO:0010744
P:positive regulation of macrophage derived foam cell differentiation
GO:0033864
P:positive regulation of NAD(P)H oxidase activity
GO:0032430
P:positive regulation of phospholipase A2 activity
GO:2000379
P:positive regulation of reactive oxygen species metabolic process
GO:0002034
P:regulation of blood vessel size by renin-angiotensin
GO:0001558
P:regulation of cell growth
GO:0042127
P:regulation of cell proliferation
GO:0035813
P:regulation of renal sodium excretion
GO:0019229
P:regulation of vasoconstriction
GO:0042312
P:regulation of vasodilation
GO:0002018
P:renin-angiotensin regulation of aldosterone production
GO:0007266
P:Rho protein signal transduction
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References (9)[1] “Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor.” Mauzy C.A.et.al. 1378723 [2] “Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor.” Furuta H.et.al. 1543512 [3] “Cloning and characterization of a human angiotensin II type 1 receptor.” Bergsma D.J.et.al. 1567413 [4] “Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor.” Takayanagi R.et.al. 1550596 | |
Structure: | |
External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MILNSSTEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFGNSLVV IVIYFYMKLK 61: TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNYL CKIASASVSF NLYASVFLLT 121: CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI IIWLLAGLAS LPAIIHRNVF FIENTNITVC 181: AFHYESQNST LPIGLGLTKN ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFK 241: IIMAIVLFFF FSWIPHQIFT FLDVLIQLGI IRDCRIADIV DTAMPITICI AYFNNCLNPL 301: FYGFLGKKFK RYFLQLLKYI PPKAKSHSNL STKMSTLSYR PSDNVSSSTK KPAPCFEVE