9.A.14.13.32
Kappa-opioid receptor, KOR, of 380 aas and 7 TMSs. Sperm-specific protein changes occur downstream of KOR in human spermatozoa (Urizar-Arenaza et al. 2019). It functions as a receptor for endogenous
alpha-neoendorphins and dynorphins, but has low affinity for
beta-endorphins. It also functions as a receptor for the psychoactive diterpene salvinorin A. Ligand binding
causes a conformation change that triggers signaling via G proteins and modulates the activity of
down-stream effectors, such as adenylate cyclase (Wu et al. 2012).
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| Accession Number: | P41145 |
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| Protein Name: | Kappa-type opioid receptor |
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| Length: | 380 |
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| Molecular Weight: | 42645.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MDSPIQIFRG EPGPTCAPSA CLPPNSSAWF PGWAEPDSNG SAGSEDAQLE PAHISPAIPV
61: IITAVYSVVF VVGLVGNSLV MFVIIRYTKM KTATNIYIFN LALADALVTT TMPFQSTVYL
121: MNSWPFGDVL CKIVISIDYY NMFTSIFTLT MMSVDRYIAV CHPVKALDFR TPLKAKIINI
181: CIWLLSSSVG ISAIVLGGTK VREDVDVIEC SLQFPDDDYS WWDLFMKICV FIFAFVIPVL
241: IIIVCYTLMI LRLKSVRLLS GSREKDRNLR RITRLVLVVV AVFVVCWTPI HIFILVEALG
301: STSHSTAALS SYYFCIALGY TNSSLNPILY AFLDENFKRC FRDFCFPLKM RMERQSTSRV
361: RNTVQDPAYL RDIDGMNKPV