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9.A.14.13.32
Kappa-opioid receptor, KOR, of 380 aas and 7 TMSs.  Sperm-specific protein changes occur downstream of KOR in human spermatozoa (Urizar-Arenaza et al. 2019). It functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. It also functions as a receptor for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via G proteins and modulates the activity of down-stream effectors, such as adenylate cyclase (Wu et al. 2012).

Accession Number:P41145
Protein Name:Kappa-type opioid receptor
Length:380
Molecular Weight:42645.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Structure:
4DJH   6B73   6VI4     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDSPIQIFRG EPGPTCAPSA CLPPNSSAWF PGWAEPDSNG SAGSEDAQLE PAHISPAIPV 
61:	IITAVYSVVF VVGLVGNSLV MFVIIRYTKM KTATNIYIFN LALADALVTT TMPFQSTVYL 
121:	MNSWPFGDVL CKIVISIDYY NMFTSIFTLT MMSVDRYIAV CHPVKALDFR TPLKAKIINI 
181:	CIWLLSSSVG ISAIVLGGTK VREDVDVIEC SLQFPDDDYS WWDLFMKICV FIFAFVIPVL 
241:	IIIVCYTLMI LRLKSVRLLS GSREKDRNLR RITRLVLVVV AVFVVCWTPI HIFILVEALG 
301:	STSHSTAALS SYYFCIALGY TNSSLNPILY AFLDENFKRC FRDFCFPLKM RMERQSTSRV 
361:	RNTVQDPAYL RDIDGMNKPV