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9.A.14.4.13
Glucagon receptor of 477 aas and 7 TMSs (Family B GPCR; Hilger et al. 2020) (MacNeil et al. 1994).  It is the G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis (Zhou et al. 2009). It does so by regulating the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis, and it mediates the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase and plays a role in signaling via a phosphatidylinositol-calcium second messenger system. The 3-D structure has been determined (Siu et al. 2013; Zhang et al. 2017).  In addition, its structure with glucagon and two distinct classes of heterotrimeric G-proteins, Gs and Gi1, has been determined (Qiao et al. 2020; Chang et al. 2020).

Accession Number:P47871
Protein Name:Glucagon receptor
Length:477
Molecular Weight:54009.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Structure:
2A83   3CZF   4ERS   4L6R   4LF3   5EE7   5XEZ   5XF1   5YQZ   6LMK   [...more]

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPPCQPQRPL LLLLLLLACQ PQVPSAQVMD FLFEKWKLYG DQCHHNLSLL PPPTELVCNR 
61:	TFDKYSCWPD TPANTTANIS CPWYLPWHHK VQHRFVFKRC GPDGQWVRGP RGQPWRDASQ 
121:	CQMDGEEIEV QKEVAKMYSS FQVMYTVGYS LSLGALLLAL AILGGLSKLH CTRNAIHANL 
181:	FASFVLKASS VLVIDGLLRT RYSQKIGDDL SVSTWLSDGA VAGCRVAAVF MQYGIVANYC 
241:	WLLVEGLYLH NLLGLATLPE RSFFSLYLGI GWGAPMLFVV PWAVVKCLFE NVQCWTSNDN 
301:	MGFWWILRFP VFLAILINFF IFVRIVQLLV AKLRARQMHH TDYKFRLAKS TLTLIPLLGV 
361:	HEVVFAFVTD EHAQGTLRSA KLFFDLFLSS FQGLLVAVLY CFLNKEVQSE LRRRWHRWRL 
421:	GKVLWEERNT SNHRASSSPG HGPPSKELQF GRGGGSQDSS AETPLAGGLP RLAESPF