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Accession Number: | Q02643 |
Protein Name: | Growth hormone-releasing hormone receptor |
Length: | 423 |
Molecular Weight: | 47402.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 7 |
Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
Substrate |
Cross database links:
Entrez Gene ID: | 2692 |
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Pfam: | PF00002 PF02793 |
KEGG: | hsa:2692 |
Gene Ontology
GO:0009986
C:cell surface
GO:0016021
C:integral to membrane
GO:0005637
C:nuclear inner membrane
GO:0016363
C:nuclear matrix
GO:0005640
C:nuclear outer membrane
GO:0005886
C:plasma membrane
GO:0030141
C:secretory granule
GO:0019838
F:growth factor binding
GO:0016520
F:growth hormone-releasing hormone receptor activity
GO:0017046
F:peptide hormone binding
GO:0007189
P:activation of adenylate cyclase activity by G-protein signaling pathway
GO:0008284
P:positive regulation of cell proliferation
GO:0060124
P:positive regulation of growth hormone secretion
GO:0043568
P:positive regulation of insulin-like growth factor receptor signaling pathway
GO:0040018
P:positive regulation of multicellular organism growth
GO:0043627
P:response to estrogen stimulus
GO:0051384
P:response to glucocorticoid stimulus
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References (7)[1] “Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone.” Mayo K.E.et.al. 1333056 [2] “Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone.” Gaylinn B.D.et.al. 7680413 [3] “The DNA sequence of human chromosome 7.” Hillier L.W.et.al. 12853948 | |
Structure: | |
External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MDRRMWGAHV FCVLSPLPTV LGHMHPECDF ITQLREDESA CLQAAEEMPN TTLGCPATWD 61: GLLCWPTAGS GEWVTLPCPD FFSHFSSESG AVKRDCTITG WSEPFPPYPV ACPVPLELLA 121: EEESYFSTVK IIYTVGHSIS IVALFVAITI LVALRRLHCP RNYVHTQLFT TFILKAGAVF 181: LKDAALFHSD DTDHCSFSTV LCKVSVAASH FATMTNFSWL LAEAVYLNCL LASTSPSSRR 241: AFWWLVLAGW GLPVLFTGTW VSCKLAFEDI ACWDLDDTSP YWWIIKGPIV LSVGVNFGLF 301: LNIIRILVRK LEPAQGSLHT QSQYWRLSKS TLFLIPLFGI HYIIFNFLPD NAGLGIRLPL 361: ELGLGSFQGF IVAILYCFLN QEVRTEISRK WHGHDPELLP AWRTRAKWTT PSRSAAKVLT 421: SMC