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9.A.14.7.1
Metabotropic glutamate receptor 1, class C.  The parallel 7 TMS dimer is mediated by cholesterol, which suggests that signaling initiated by glutamate's interaction with the extracellular domain might be mediated via 7 TMS interactions within the full-length receptor dimer (Wu et al. 2014). This protein appears to be involved in regulation of  the functions of glycine receptors (see TC# 1.A.9.3.1) (Zhang et al. 2019).

Accession Number:Q13255
Protein Name:Metabotropic glutamate receptor 1
Length:1194
Molecular Weight:132357.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

Entrez Gene ID: 2911   
Pfam: PF00003    PF01094    PF10606    PF07562   
KEGG: hsa:2911    hsa:2911   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0004930 F:G-protein coupled receptor activity
GO:0008066 F:glutamate receptor activity
GO:0007268 P:synaptic transmission

References (16)

[1] “Cloning and expression of a human metabotropic glutamate receptor 1 alpha: enhanced coupling on co-transfection with a glutamate transporter.”  Desai M.A.et.al.   7476890
[2] “Human metabotropic glutamate receptor 1: mRNA distribution, chromosome localization and functional expression of two splice variants.”  Stephan D.et.al.   9076744
[3] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Cys-140 is critical for metabotropic glutamate receptor-1 dimerization.”  Ray K.et.al.   10945991
[6] “Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling.”  Wang Y.et.al.   17053785
[7] “Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.”  Imami K.et.al.   18187866
[8] “The consensus coding sequences of human breast and colorectal cancers.”  Sjoeblom T.et.al.   16959974
[9] “Cloning and expression of a human metabotropic glutamate receptor 1 alpha: enhanced coupling on co-transfection with a glutamate transporter.”  Desai M.A.et.al.   7476890
[10] “Human metabotropic glutamate receptor 1: mRNA distribution, chromosome localization and functional expression of two splice variants.”  Stephan D.et.al.   9076744
[11] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[12] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[13] “Cys-140 is critical for metabotropic glutamate receptor-1 dimerization.”  Ray K.et.al.   10945991
[14] “Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling.”  Wang Y.et.al.   17053785
[15] “Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.”  Imami K.et.al.   18187866
[16] “The consensus coding sequences of human breast and colorectal cancers.”  Sjoeblom T.et.al.   16959974
Structure:
3KS9   4OR2     

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVGLLLFFFP AIFLEVSLLP RSPGRKVLLA GASSQRSVAR MDGDVIIGAL FSVHHQPPAE 
61:	KVPERKCGEI REQYGIQRVE AMFHTLDKIN ADPVLLPNIT LGSEIRDSCW HSSVALEQSI 
121:	EFIRDSLISI RDEKDGINRC LPDGQSLPPG RTKKPIAGVI GPGSSSVAIQ VQNLLQLFDI 
181:	PQIAYSATSI DLSDKTLYKY FLRVVPSDTL QARAMLDIVK RYNWTYVSAV HTEGNYGESG 
241:	MDAFKELAAQ EGLCIAHSDK IYSNAGEKSF DRLLRKLRER LPKARVVVCF CEGMTVRGLL 
301:	SAMRRLGVVG EFSLIGSDGW ADRDEVIEGY EVEANGGITI KLQSPEVRSF DDYFLKLRLD 
361:	TNTRNPWFPE FWQHRFQCRL PGHLLENPNF KRICTGNESL EENYVQDSKM GFVINAIYAM 
421:	AHGLQNMHHA LCPGHVGLCD AMKPIDGSKL LDFLIKSSFI GVSGEEVWFD EKGDAPGRYD 
481:	IMNLQYTEAN RYDYVHVGTW HEGVLNIDDY KIQMNKSGVV RSVCSEPCLK GQIKVIRKGE 
541:	VSCCWICTAC KENEYVQDEF TCKACDLGWW PNADLTGCEP IPVRYLEWSN IESIIAIAFS 
601:	CLGILVTLFV TLIFVLYRDT PVVKSSSREL CYIILAGIFL GYVCPFTLIA KPTTTSCYLQ 
661:	RLLVGLSSAM CYSALVTKTN RIARILAGSK KKICTRKPRF MSAWAQVIIA SILISVQLTL 
721:	VVTLIIMEPP MPILSYPSIK EVYLICNTSN LGVVAPLGYN GLLIMSCTYY AFKTRNVPAN 
781:	FNEAKYIAFT MYTTCIIWLA FVPIYFGSNY KIITTCFAVS LSVTVALGCM FTPKMYIIIA 
841:	KPERNVRSAF TTSDVVRMHV GDGKLPCRSN TFLNIFRRKK AGAGNANSNG KSVSWSEPGG 
901:	GQVPKGQHMW HRLSVHVKTN ETACNQTAVI KPLTKSYQGS GKSLTFSDTS TKTLYNVEEE 
961:	EDAQPIRFSP PGSPSMVVHR RVPSAATTPP LPSHLTAEET PLFLAEPALP KGLPPPLQQQ 
1021:	QQPPPQQKSL MDQLQGVVSN FSTAIPDFHA VLAGPGGPGN GLRSLYPPPP PPQHLQMLPL 
1081:	QLSTFGEELV SPPADDDDDS ERFKLLQEYV YEHEREGNTE EDELEEEEED LQAASKLTPD 
1141:	DSPALTPPSP FRDSVASGSS VPSSPVSESV LCTPPNVSYA SVILRDYKQS SSTL