TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
9.A.35.1.1









Syndecan-4 of 198 aas.  Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. The syndecan-syntenin-ALIX complex plays a role  in membrane transport and signalling processes (Baietti et al. 2012). ESCRT-to-membrane coupling via ALIX/syntenin/syndecan-4 is required for completion of cytokinesis (Addi et al. 2020). Plays a role in SARS-CoV2 entry (see family description) (Hudák et al. 2021).

Eukaryota
Metazoa
Syndecan-4 of Homo sapiens (P31431)
9.A.35.1.2









Syndecan-1 of 310 aas and 2 TMSs, N- and C-terminal.  The binding of cytokines and growth factors to heparan sulfate (HS) chains on proteoglycans generates gradients that control development and regulate wound healing. Syndecan-1 (sdc1) is an integral membrane HS proteoglycan. Its structure allows it to bind with cytosolic, transmembrane, and extracellular matrix (ECM) proteins. It plays important roles in mediating key events during wound healing because it regulates a number of important processes, including cell adhesion, cell migration, endocytosis, exosome formation, and fibrosis (Stepp et al. 2015). Syndecan-1 mediates sorting of soluble lipoprotein lipase into sphingomyelin-rich membranes in the golgi apparatus (Sundberg et al. 2019).

Eukaryota
Metazoa
Syndecan-1 of Homo sapiens
9.A.35.1.3









Uncharacterized protein of 220 aas and 2 TMSs.

Eukaryota
Opisthokonta
UP of Coptotermes formosanus (Formosan subterranean termite)
9.A.35.1.4









Syndecan-3 of 346 aas and 1 TMS, near the C-terminus.

Eukaryota
Opisthokonta
Syndecan-3 of Globicephala melas (long-finned pilot whale)
9.A.35.1.5









Uncharacterized protein of 488 aas and 1 TMS

Eukaryota
Opisthokonta
UP of Trichogramma brassicae
9.A.35.1.6









Uncharacterized protein of 248 aas and 1 TMS.

Eukaryota
Opisthokonta
UP of Didymodactylos carnosus