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9.A.35.1.1
Syndecan-4 of 198 aas.  Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. The syndecan-syntenin-ALIX complex plays a role  in membrane transport and signalling processes (Baietti et al. 2012). ESCRT-to-membrane coupling via ALIX/syntenin/syndecan-4 is required for completion of cytokinesis (Addi et al. 2020). Plays a role in SARS-CoV2 entry (see family description) (Hudák et al. 2021).

Accession Number:P31431
Protein Name:Syndecan-4
Length:198
Molecular Weight:21642.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type I membrane protein2
Substrate

Cross database links:

DIP: DIP-29945N
RefSeq: NP_002990.2   
Entrez Gene ID: 6385   
Pfam: PF01034   
OMIM: 600017  gene
KEGG: hsa:6385   

Gene Ontology

GO:0005794 C:Golgi apparatus
GO:0005887 C:integral to plasma membrane
GO:0070053 F:thrombospondin receptor activity

References (11)

[1] “Molecular cloning of amphiglycan, a novel integral membrane heparan sulfate proteoglycan expressed by epithelial and fibroblastic cells.”  David G.et.al.   1500433
[2] “Human ryudocan core protein: molecular cloning and characterization of the cDNA, and chromosomal localization of the gene.”  Kojima T.et.al.   7916598
[3] “Structural organization and promoter activity of the human ryudocan gene.”  Takagi A.et.al.   8797100
[4] “The DNA sequence and comparative analysis of human chromosome 20.”  Deloukas P.et.al.   11780052
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Adhesion signaling by a novel mitotic substrate of src kinases.”  Bhatt A.S.et.al.   16007225
[7] “Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.”  Rikova K.et.al.   18083107
[8] “An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells.”  Heibeck T.H.et.al.   19534553
[9] “Solution structure of the dimeric cytoplasmic domain of syndecan-4.”  Shin J.et.al.   11456484
[10] “Molecular roots of degenerate specificity in syntenin's PDZ2 domain: reassessment of the PDZ recognition paradigm.”  Kang B.S.et.al.   12842047
[11] “The binding of the PDZ tandem of syntenin to target proteins.”  Grembecka J.et.al.   16533050
Structure:
1EJP   1EJQ   1OBY   1YBO     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MAPARLFALL LFFVGGVAES IRETEVIDPQ DLLEGRYFSG ALPDDEDVVG PGQESDDFEL 
61:	SGSGDLDDLE DSMIGPEVVH PLVPLDNHIP ERAGSGSQVP TEPKKLEENE VIPKRISPVE 
121:	ESEDVSNKVS MSSTVQGSNI FERTEVLAAL IVGGIVGILF AVFLILLLMY RMKKKDEGSY 
181:	DLGKKPIYKK APTNEFYA