9.A.35.1.7
Syndecan-1, SDN-1, of 287 aas and 1 C-terminal TMS. SDN-1 controls a somatic TRP calcium channel and governs calcium-dependent binding of an AP-2 transcription factor (APTF-2) to the glp-1 promoter. SDN-1 signaling promotes GLP-1 expression and mitotic germ cell fate. Thus, SDN-1 is a putative communication nexus between the germline and its somatic environment to control germ cell fate decisions (Gopal et al. 2021).
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| Accession Number: | Q8I4H9 |
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| Protein Name: | Syndecan |
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| Length: | 287 |
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| Molecular Weight: | 30851.00 |
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| Species: | Caenorhabditis elegans [6239] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MILKLNFCLS TYSVLILLSL STQAFAANQA KTKVVPSSTI STKSLKNGIS EVEGSANIPG
61: RLADIEVNGS GYPTDDEDGD DVHGSGKPPS SATTKSDKVT SPSHAVVTAK PTTVPTTTAS
121: FKPPVQPKPK PAANDKEIKV EEDEDDDEDE DEDDEDDEED FADENIHNDE DFFTTTTTTT
181: YRPIVVATTS TPRSAATNPP RQQPPMVTST ISSGPFSPFH ETLANGFYAA IAGGVLVAVI
241: TAILLVLFVV FRIRKKDEGS YALDEPKQAR PYASYGYTKA STKEFYA