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9.A.51 The Francisella Siderophore Transporter (FST) Family

Strains of Francisella tularensis secrete a siderophore in response to iron limitation. Siderophore production is dependent on fslA, the first gene in an operon that appears to encode biosynthetic and export functions for the siderophore. Transcription of the operon is induced under conditions of iron limitation. FslE (544aas; locus FTT0025 in the Schu S4 genome), located downstream of the siderophore biosynthetic genes, is under Fur regulation and is transcribed as part of the fslABCDEF operon. Ramakrishnan et al. (2008) generated an in-frame deletion of FslE and found that the mutant was defective for growth under iron limitation. The mutant was able to secrete a siderophore but was defective in utilization of the siderophore.
FslE belongs to a family of proteins that has no known homologs outside of Francisella species. The fslE gene product has been localized to the outer membrane of F. tularensis strains. FslE may function as a siderophore receptor in F. tularensis. It shows striking sequence similarity to glycine-rich autotransporters and contains a sequence (residue 114-457) that is repeated at least seven times in an autotransporter protein (TC#1.B.12) of 4234aas (CAR57253).

The reaction catalyzed by FslE is:

siderophore (out)siderophore (periplasm)

References associated with 9.A.51 family:

Ramakrishnan, G., A. Meeker, and B. Dragulev. (2008). fslE is necessary for siderophore-mediated iron acquisition in Francisella tularensis Schu S4. J. Bacteriol. 190: 5353-5361. 18539739