TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


9.A.8.1.15
FeoB of 766 aas and 10 TMSs, a potential GTP hydrolysis-driven active transporter or GTP-activated iron uptake channel. The membrane domain of the trimeric FeoB forms a central pore lined by highly conserved cysteine residues. This pore aligns with a central pore in the N-terminal GTPase domain (G-domain) which is lined by aspartyl residues. Biochemical analyses revealed a putative iron sensor domain that could connect GTP binding/hydrolysis to the opening of the pore. Thus, FeoB may be a GTP-gated channel or GTP hydrolysis-driven primary active transporter (Seyedmohammad et al. 2016).

Accession Number:W1MMS7
Protein Name:Ferrous iron transport protein B
Length:766
Molecular Weight:82470.00
Species:Pseudomonas aeruginosa VRFPA03 [1350465]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell inner membrane1
Substrate Fe2+

Cross database links:

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MTALTLGLIG NPNSGKTTLF NQLTGSRQRV GNWAGVTVER KEGAFHTARH AVRLVDLPGT 
61:	YSLTSVSAQA SLDEQIACRY IASGEVDVLV NVVDAANLER NLYLTVQLRE MGIPCIVALN 
121:	MLDIARSQRI RIDIDGLARR LGCPVVPLVS TRADGIDELK AAIDELQVPQ AALAVDYPPA 
181:	IQAQVGYLLE TRAPAASAIE PRWLALQALE GDIFNGPALG LPPATLEQAR RGCGEEPELA 
241:	IVDARYRLIG EICAAVCDHQ QAQPHRLTQW LDRVVLNRWL GLPIFLLVMY LMFFFAINIG 
301:	GALQPIFDKG SSAIFIDGIQ WLGIRFGLPD WLTAFLAQGI GGGVNTVLPL VPQIGLMYLF 
361:	LSLLEDSGYM ARAAFVMDRL MQALGLPGKS FVPLIVGFGC NVPSIMGART LDAQRERLIT 
421:	IMMAPFMSCG ARLAIFAVFA GAFFGQGGAL VIFSLYLLGI VVAILTGLLL KHTLMRGEAS 
481:	PFVMELPLYH VPHLKSLLLQ TWSRLRGFVV RAGKVIILVS LVIGGLNSIT LDGKPVQGDI 
541:	GHSALASVSQ RLTPLLAPLG VQPDNWQATV GLVTGAMAKE VVVGTLNTLY TAEQIQGEAF 
601:	DYEGYDLPGQ LRDALVETWD GLVDTFSLSV LANPVEASMA DGDMETGSMG TMASKFGSPI 
661:	AAYSYLVFVL LYVPCVTAMG AIARESSKGW MAFSVLWGLN VAYSLATLCY QVATFAAHPE 
721:	RSVLTIAVVL LFNLILMTCL RLFGREQVLQ LPGRMADAPS GQGGCH