9.B.101.1.1
Cytotoxin-associated gene product, CagA. It may mediate carcinogenesis in the human stomach (Sibony and Jones, 2012). (May be related to VacA and other Cag pathogenicity island proteins (Gangwer et al., 2010)).
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| Accession Number: | O07910 |
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| Protein Name: | CagA |
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| Length: | 1247 |
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| Molecular Weight: | 138820.00 |
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| Species: | Helicobacter pylori [210] |
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| Substrate |
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| Pfam: |
PF03507
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[1] “Determination of Helicobacter pylori virulence by simple gene analysis of the cag pathogenicity island.” Ikenoue T. et.al. 11139216
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1: MTNETIAQQP QTEAAFNPQQ FINNLQVAFL KVDNAVASYD PDQKPIVDKN DRDNRQAFDG
61: ISQLREEYSN KAIKNPTKKN QYFSDFINKS NDLINKDNLI DIGSSIKSFQ KFGTQRYRIF
121: TSWVSHQNDP SKINTRSIRN FMENIIQPPT PDDKERAEFV KSAKQSFAGI IIGNQIRTDQ
181: KFMGVFDEFL KERQEAEKNG EPTGGDWLDI FLSFVFNKEQ SSDVKEAINQ EPVPHVQPDI
241: ATTTTHIQGL PPESRDLLDE RGNFSKFTLG DMEMLDVEGV ADIDPNYKFN QLLIHNNALS
301: SVLMGSHNGI EPEKVSLLFA GNGGFGAKHD WNATVGYKNQ QGDNVATLIN VHMKNGSGLV
361: IAGGEKGINN PSFYLYKEDQ LTGSQRALSQ EEIRNKIDFM EFLAQNNAKL DNLSEKEKEK
421: FQNEIEDFQK DSKAYLDALG NDRIAFVSKK DPKHPALITE FGKGDLSYTL KVMGKKQTEA
481: LDREKNVTLQ GNLKHDSVMF VNYSNFKYTN ASKSPDKGVG VTNGVSHLDA GFSKVAVFNL
541: PDLNNLAITS FVRRNLENKL VTEGLSLQEA NKLIKDFLSS NKELVGKALN FNKAVADAKN
601: TGDYDEVKKA QKDLEKSLRK REHLEKEVEK KLETKSGNKN KMEAKAQANG QKDKIFALIN
661: KEANRDARAI AYSQNLKGIK RELSDKLEKI NTDLKDFSKS FDEFKNGKNK DFSKAEETLK
721: ALKGSVKDLG INPEWISKVE NLNAALNEFK NGKNKDFSKV TQAKSDLENS VKDVIINQKI
781: TDKVDNLNQA VSMAKATGGF SRVEQALADL KNFSKEQLAQ QTQKNESFNV GKKSEIYQSV
841: KNGVNGTLVG NGLSGIEATA LAKNFSDIKK ELNEKFKNFN NNNNNGLENE PIYAKVNKKK
901: TGQVASPEEP IYAQVAKKVN AKIDRLNQAA SGLGGVGQAG FPLKRHDKVD DLSKVGRSVS
961: PEPIYATIDD LGGPFPSKRH DKVDDLSKVG RSVSPEPIYA TIDDLGGPFP LKRHDKVDDL
1021: SKVGRSVSPE PIYATIDDLG GPFPSKRHDK VDDLSKVGLS RNQELAQKID NLSQAVSEAK
1081: AGFFSNLEQT IDKLKDSTKY NSVNLWVESA QKVPASLSAK LDNYATNSHT RINSNIQNGA
1141: INEKATGMLT HKNPEWLKLV NDKIVAHNVG SVPLSEYDKI GFNQKNMKDY SDSFKFSTKL
1201: NNAVKDVKSS FTQFLANAFS TGYYSLAREN AEHGIKNVNT KGGFQKS