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9.B.102 The YedE/YeeE (YeeE) Family

The YeeE family (also called the COG2392 or DUF395 family) consists of numerous putative transport proteins of from 4 to 10 TMSs (G Madrigal, P Kabran and M Saier, unpublished observations). Some of these (i.e PmpA and PmpB, both of 4 TMSs) may function together as a heterodimeric transporter. In some cases, two YeeE homologues are encoded in a single operon with a member of the TSUP family e.g., PmpC (2.A.102.4.2; Gristwood et al., 2011). Some evidence suggests that some of these proteins may play a role in sulfur and/or selenium metabolism (Lin et al. 2015). The smaller proteins (4 - 6 TMSs) have one of two conserved, related motifs, A or B, while the larger proteins (9 - 10 TMSs) have both in either of the two possible orders, A - B or B - A within two repeat segemnts of 5 TMSs (unpublished results). 

References associated with 9.B.102 family:

Bagchi, A. (2013). Structural analyses of the permease like protein SoxT: a member of the sulfur compound metabolizing sox operon. Gene 521: 207-210. 23500599
Dahl, J.U., C. Radon, M. Bühning, M. Nimtz, L.I. Leichert, Y. Denis, C. Jourlin-Castelli, C. Iobbi-Nivol, V. Méjean, and S. Leimkühler. (2013). The sulfur carrier protein TusA has a pleiotropic role in Escherichia coli that also affects molybdenum cofactor biosynthesis. J. Biol. Chem. 288: 5426-5442. 23281480
Darshan, N. and H.K. Manonmani. (2015). Prodigiosin and its potential applications. J Food Sci Technol 52: 5393-5407. 26344956
Gristwood, T., M.B. McNeil, J.S. Clulow, G.P. Salmond, and P.C. Fineran. (2011). PigS and PigP regulate prodigiosin biosynthesis in Serratia via differential control of divergent operons, which include predicted transporters of sulfur-containing molecules. J. Bacteriol. 193: 1076-1085. 21183667
Higgins, K.A., H. Peng, J.L. Luebke, F.M. Chang, and D.P. Giedroc. (2015). Conformational analysis and chemical reactivity of the multidomain sulfurtransferase, Staphylococcus aureus CstA. Biochemistry 54: 2385-2398. 25793461
Joshi, R. and B.B. McSpadden Gardener. (2006). Identification and Characterization of Novel Genetic Markers Associated with Biological Control Activities in Bacillus subtilis. Phytopathology 96: 145-154. 18943917
Lahiri, C., S. Mandal, W. Ghosh, B. Dam, and P. Roy. (2006). A novel gene cluster soxSRT is essential for the chemolithotrophic oxidation of thiosulfate and tetrathionate by Pseudaminobacter salicylatoxidans KCT001. Curr. Microbiol. 52: 267-273. 16528465
Lee, J., S. Ghosh, and M.H. Saier, Jr. (2017). Comparative genomic analyses of transport proteins encoded within the red algae Chondrus crispus, Galdieria sulphuraria, and Cyanidioschyzon merolae(11). J Phycol 53: 503-521. 28328149
Lee, K.Y., J.H. Kim, K.Y. Lee, J. Lee, I. Lee, Y.J. Bae, and B.J. Lee. (2013). Structural characterization of HP1264 reveals a novel fold for the flavin mononucleotide binding protein. Biochemistry 52: 1583-1593. 23406339
Lin, J., T. Peng, L. Jiang, J.Z. Ni, Q. Liu, L. Chen, and Y. Zhang. (2015). Comparative genomics reveals new candidate genes involved in selenium metabolism in prokaryotes. Genome Biol Evol 7: 664-676. 25638258
Salazar, J.K., K. Deng, M.L. Tortorello, M.T. Brandl, H. Wang, and W. Zhang. (2013). Genes ycfR, sirA and yigG contribute to the surface attachment of Salmonella enterica Typhimurium and Saintpaul to fresh produce. PLoS One 8: e57272. 23451197
Shlykov, M.A., W.H. Zheng, J.S. Chen, and M.H. Saier, Jr. (2012). Bioinformatic characterization of the 4-Toluene Sulfonate Uptake Permease (TSUP) family of transmembrane proteins. Biochim. Biophys. Acta. 1818: 703-717. 22192777
Stockdreher, Y., M. Sturm, M. Josten, H.G. Sahl, N. Dobler, R. Zigann, and C. Dahl. (2014). New proteins involved in sulfur trafficking in the cytoplasm of Allochromatium vinosum. J. Biol. Chem. 289: 12390-12403. 24648525
Teplitski, M., A. Al-Agely, and B.M. Ahmer. (2006). Contribution of the SirA regulon to biofilm formation in Salmonella enterica serovar Typhimurium. Microbiology 152: 3411-3424. 17074910