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9.B.105.1.1
PbrB/C fusion protein of 358 aas and 10 - 12 TMSs. Confers resistance to Pb2+ (Taghavi et al., 2009).  May be a phosphatase. While PbrA non-specifically exported Pb2+, Zn2+ and Cd2+, a specific increase in lead resistance is observed when PbrA and PbrB are coexpressed. Possibly Pb2+ is exported from the cytoplasm by PbrA and then sequestered as a phosphate salt with the inorganic phosphate produced by PbrB. Similar operons containing genes for heavy metal translocating ATPases and phosphatases can be found in many different bacterial species, suggesting that lead detoxification through active efflux and sequestration is a common lead-resistance mechanism (Hynninen et al. 2009).

Accession Number:Q58AJ7
Protein Name:PbrB/pbrC lead resistance fusion protein
Length:358
Molecular Weight:38446.00
Species:Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) [266264]
Number of TMSs:10
Substrate Unknown

Cross database links:

Entrez Gene ID: 3170446    4036386   
Pfam: PF01569    PF01252   
KEGG: rme:Rmet_5948   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0004190 F:aspartic-type endopeptidase activity
GO:0006508 P:proteolysis

References (2)

[1] “The czc operon of Alcaligenes eutrophus CH34: from resistance mechanism to the removal of heavy metals.”  Diels L.et.al.   7766206
[2] “Cloning and functional analysis of the pbr lead resistance determinant of Ralstonia metallidurans CH34.”  Borremans B.et.al.   11544228

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSWKAIFYDW GGLNGALFQL INAATPAFLM PLAWLFSNVL GNYWTAPVVV LGLWAWSSST 
61:	AEARRTMAIR CQLLQFVVGF GIAFAIASCL KLGLDFPRPA AVFGQLDHVL GTVEERYSLP 
121:	SGHSTYAALV AGALWPLLGI RRRLALIVYV VLVGWSRIAA GMHFPADVLA GWGIATVSLM 
181:	LAGFLVRMLP GAIRTMATRA SGAWYALAAA VLLGDQLAKT VISQLFGYGE QVGITPFFNL 
241:	VHVRNNGAAF SLLAGAGVWA RVGFAALAMC ISLWLIDQLR RGAPRWEAAG YCLILGGALG 
301:	NAADRLLRGA VVDFLDFHWR GTHWPAFNLA DVAITVGAVC LIVATRRRGG QIRANSTA