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TCID	Name	Domain	Kingdom/Phylum	Protein(s)
9.B.105.1.1	PbrB/C fusion protein of 358 aas and 10 - 12 TMSs. Confers resistance to Pb²⁺ (Taghavi et al., 2009). May be a phosphatase. While PbrA non-specifically exported Pb²⁺, Zn²⁺ and Cd²⁺, a specific increase in lead resistance is observed when PbrA and PbrB are coexpressed. Possibly Pb²⁺ is exported from the cytoplasm by PbrA and then sequestered as a phosphate salt with the inorganic phosphate produced by PbrB. Similar operons containing genes for heavy metal translocating ATPases and phosphatases can be found in many different bacterial species, suggesting that lead detoxification through active efflux and sequestration is a common lead-resistance mechanism (Hynninen et al. 2009).	Bacteria	Pseudomonadota	PbrB/C fusion protein of Ralstonia (Cupriavidus) metallidurans (Q58AJ7)
9.B.105.1.2	Hypothetical protein, HEAR1543. Residues 1-200 45% identity to PbrB which has 312 aas with 6 TMSs. The c-terminal domain contains a DUF3703 domain.	Bacteria	Pseudomonadota	HEAR1543 of Herminiimonas arsenicoxydans (A4G5C1)
9.B.105.1.3	Undecaprenyl-diphosphatase BcrC (EC 3.6.1.27) (Undecaprenyl pyrophosphate phosphatase)	Bacteria	Bacillota	bcrC of Bacillus subtilis
9.B.105.1.4	Hypothetical protein	Bacteria	Planctomycetota	HP of Rhodopirellula baltica
9.B.105.1.5	Lipoprotein signal peptidase of the Peptidase A8 Superfamily; IspA: geranyltranstransferase (Farnesyl-diphosphate synthase).	Bacteria	Bacillota	Peptidase of Clostridium cellulolyticum
9.B.105.1.6	Putative phosphatase of 178 aas and 4 TMSs.	Bacteria	Spirochaetota	Putative phosphatase of Leptospira interrogans
9.B.105.1.7	Uncharacterized protein of 188 aas and 5 or 6 TMSs	Bacteria	Bdellovibrionota	UP of Bdellovibrio bacteriovorus
9.B.105.1.8	Lipoprotein signal peptidase of 310 aas and 6 TMSs, IspA.	Bacteria	Bdellovibrionota	IspA of Bdellovibrio bacteriovorus
9.B.105.1.9	Uncharacterized protein of 141 aas and 4 TMSs (Hug et al. 2016).	Bacteria	Candidatus Peregrinibacteria	UP of Candidatus Peribacter riflensis
9.B.105.1.10	Plasma-membrane-bound acidic pyrophosphatase (exo-PPase) of 206 aas and 5 TMSs. It represents proteins with the conserved phosphatase motif KxxxxxRP-(x12-54)-PSGH-(x31-54)-SRxxxxxHxxxD. Phosphatase or pyrophosphatase activity was described for the Sulfolobus acidocaldarius protein. It may function in resistance to the peptide antibiotic bacitracin (Moll and Schäfer 2004).	Archaea	Thermoproteota	ExoPPase of Sulfolobus acidocaldarius
9.B.105.2.1	Putative phosphatase of 321 aas and 9 TMSs	Bacteria	Spirochaetota	Putative phosphatase of Leptospira interrogans
9.B.105.2.2	Membrane-associated phospholipid phosphatase of 223 aas and 6 TMSs.	Bacteria	Bacillota	Phosphatase of Lactobacillus paracasei
9.B.105.2.3	YodM (PgpB), the principal phosphatidylglycerol phosphate (PGP) phosphatase of 203 aas and 5 or 6 TMSs in B. subtilis. The crystal structure is known (Ghachi et al. 2017).	Bacteria	Bacillota	PgpB of Bacillus subtilis
9.B.105.2.4	Phosphatase PAP2 family proteinof 237 aas and 6 TMSs.	Bacteria	Pseudomonadota	PAP2 family protein of Maritimibacter alkaliphilus
9.B.105.3.1	Putative phosphatidate phosphatase of 412 aas and 8 TMSs, Ppp	Eukaryota	Metazoa, Arthropoda	Ppp of Lucilia cuprina
9.B.105.3.2	Diacylglycerol pyrophosphate (DGPP) phosphatase catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). It regulates intracellular DGPP and PA levels, which play a signaling role in stress responses. Can also use lysophosphatidic acid (LPA) and phosphatidylglycerophosphate as substrates. Substrate preference is DGPP > LPA > PA. Activity is independent of a divalent cation ion (Wu et al. 1996). The protein probably has 6 TMSs with two 3-TMS repeats.	Eukaryota	Fungi, Ascomycota	DGPP phosphatase of Saccharomyces cerevisiae (Baker's yeast)
9.B.105.3.3	Putative phosphatase of 223 aas and 5 TMSs.	Bacteria	Bdellovibrionota	Putative phosphatase of Bdellovibrio exovorus
9.B.105.3.4	Putative phospholipid phosphatase of 326 aas and 8 TMSs	Bacteria	Bacillota	PL phosphatase of Lactobacillus rhamnosis
9.B.105.3.5	Highly similar to Homo sapiens plasticity related gene 3 (PRG-3) of 301 aas and 5 or 6 putative TMSs.	Eukaryota	Metazoa, Chordata	PRG3 of Homo sapiens
9.B.105.4.1	Uncharacterized protein of 217 aas and 8 TMSs in a 2 + 2 + 2 + 2 arrangement.	Bacteria	Bacillota	UP of Desulfitobacterium hafniense
9.B.105.4.2	Uncharacterized protein of 201 aas and 6 TMSs. Annotated as a phosphoesterase PA-phosphatase-like protein of the PAP2 superfamily.	Archaea	Euryarchaeota	PAP2 protein of Methanobacterium formicicum
9.B.105.4.3	Uncharacterized protein of 206 aas and 6 TMSs. Shows some sequence similarity with 9.A.29.3.2 (e-valute of 0.0008 over 118 aas).	Bacteria	Actinomycetota	UP of Streptomyces sulphureus
9.B.105.4.4	Putative uncharacterized phosphatase of 191 aas and 6 TMSs.	Bacteria	Candidatus Beckwithbacteria	PAP2 family protein of Candidatus Beckwithbacteria bacterium
9.B.105.4.5	Putative phosphatase PAP2 family protein of 193 aas and 6 TMSs.	Bacteria	Actinomycetota	PAP2 family protein of Micromonospora wenchangensis
9.B.105.4.6	Uncharacterized protein of 230 aas and 6 putative TMSs	Bacteria	Bacteroidota	UP of Chitinophaga sp.
9.B.105.4.7	Phosphatase PAP2 family protein of 197 aas and 6 TMSs.	Bacteria	Actinomycetota	PAP2 family protein of Rathayibacter sp.
9.B.105.5.1	PAP2 family phosphodiesterase of 239 aas and 5 TMSs.	Bacteria	Bdellovibrionota	PAP2 protein of Bdellovibrio exovorus
9.B.105.5.2	Putative phosphodiesterase of 323 aas and 4 - 6 TMSs.	Bacteria	Bacteroidota	Phosphodiesterase of Bacteroides ovatu
9.B.105.5.3	Phosphoesterase PA-phosphatase related protein of 234 aas and 6 probable TM	Bacteria	Gemmatimonadota	Phosphatase of Gemmatirosa kalamazoonesis
9.B.105.6.1	Uncharacterised protein of 308 aas and 8 TMSs	Bacteria	Actinomycetota	UP of Dermatophilus congolensis
9.B.105.6.2	Phosphatase PAP2 family protein of 357 aas and 8 TMSs.	Bacteria	Actinomycetota	PAP2 family protein of Bombiscardovia coagulans
9.B.105.6.3	Uncharacterized protein of 388 aas and 8 TMSs in a 1 + 5 + 2 arrangement.	Bacteria	Actinomycetota	UP of Tetrasphaera japonica