9.B.105.3.2
Diacylglycerol pyrophosphate (DGPP) phosphatase catalyzes
the dephosphorylation of diacylglycerol diphosphate (DGPP) to
phosphatidate (PA) and the subsequent dephosphorylation of PA to
diacylglycerol (DAG). It regulates intracellular DGPP
and PA levels, which play a
signaling role in stress responses. Can also use lysophosphatidic acid
(LPA) and phosphatidylglycerophosphate as substrates. Substrate
preference is DGPP > LPA > PA. Activity is independent of a
divalent cation ion (Wu et al. 1996). The protein probably has 6 TMSs with two 3-TMS repeats.
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| Accession Number: | Q05521 |
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| Protein Name: | Diacylglycerol pyrophosphate phosphatase 1 |
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| Length: | 289 |
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| Molecular Weight: | 33514.00 |
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| Species: | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292] |
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| Number of TMSs: | 5 |
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| Location1 / Topology2 / Orientation3: |
Vacuole membrane1 / Multi-pass membrane protein2 |
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| Substrate |
phosphatidic acid, 1,2-diacylglycerol 3-diphosphate, 1-acyl-sn-glycerol 3-phosphate |
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1: MNRVSFIKTP FNIGAKWRLE DVFLLIIMIL LNYPVYYQQP FERQFYINDL TISHPYATTE
61: RVNNNMLFVY SFVVPSLTIL IIGSILADRR HLIFILYTSL LGLSLAWFST SFFTNFIKNW
121: IGRLRPDFLD RCQPVEGLPL DTLFTAKDVC TTKNHERLLD GFRTTPSGHS SESFAGLGYL
181: YFWLCGQLLT ESPLMPLWRK MVAFLPLLGA ALIALSRTQD YRHHFVDVIL GSMLGYIMAH
241: FFYRRIFPPI DDPLPFKPLM DDSDVTLEEA VTHQRIPDEE LHPLSDEGM