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9.B.105.3.2
Diacylglycerol pyrophosphate (DGPP) phosphatase catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). It regulates intracellular DGPP and PA levels, which play a signaling role in stress responses. Can also use lysophosphatidic acid (LPA) and phosphatidylglycerophosphate as substrates. Substrate preference is DGPP > LPA > PA. Activity is independent of a divalent cation ion (Wu et al. 1996).  The protein probably has 6 TMSs with two 3-TMS repeats.

Accession Number:Q05521
Protein Name:Diacylglycerol pyrophosphate phosphatase 1
Length:289
Molecular Weight:33514.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate Diacylglycerol pyrophosphate, Lysophosphatidic acid, Phosphatidate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNRVSFIKTP FNIGAKWRLE DVFLLIIMIL LNYPVYYQQP FERQFYINDL TISHPYATTE 
61:	RVNNNMLFVY SFVVPSLTIL IIGSILADRR HLIFILYTSL LGLSLAWFST SFFTNFIKNW 
121:	IGRLRPDFLD RCQPVEGLPL DTLFTAKDVC TTKNHERLLD GFRTTPSGHS SESFAGLGYL 
181:	YFWLCGQLLT ESPLMPLWRK MVAFLPLLGA ALIALSRTQD YRHHFVDVIL GSMLGYIMAH 
241:	FFYRRIFPPI DDPLPFKPLM DDSDVTLEEA VTHQRIPDEE LHPLSDEGM