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| Accession Number: | P38631 |
| Protein Name: | 1,3-beta-glucan synthase component FKS1 |
| Length: | 1876 |
| Molecular Weight: | 214851.00 |
| Species: | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292] |
| Number of TMSs: | 16 |
| Location1 / Topology2 / Orientation3: | Mitochondrion1 |
| Substrate | |
Cross database links:
| DIP: | DIP-5749N |
|---|---|
| Entrez Gene ID: | 851055 |
| Pfam: | PF02364 |
| KEGG: | sce:YLR342W |
Gene Ontology
GO:0000148
C:1,3-beta-D-glucan synthase complex
GO:0030478
C:actin cap
GO:0030479
C:actin cortical patch
GO:0016021
C:integral to membrane
GO:0005624
C:membrane fraction
GO:0005739
C:mitochondrion
GO:0003843
F:1,3-beta-D-glucan synthase activity
GO:0005515
F:protein binding
GO:0006075
P:(1->3)-beta-D-glucan biosynthetic process
GO:0007047
P:cellular cell wall organization
GO:0045807
P:positive regulation of endocytosis
GO:0008360
P:regulation of cell shape
GO:0008361
P:regulation of cell size
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References (20)[1] “The yeast FKS1 gene encodes a novel membrane protein, mutations in which confer FK506 and cyclosporin A hypersensitivity and calcineurin-dependent growth.” Eng W.-K.et.al. 7530227 [2] “The Saccharomyces cerevisiae FKS1 (ETG1) gene encodes an integral membrane protein which is a subunit of 1,3-beta-D-glucan synthase.” Douglas C.M.et.al. 7528927 [3] “Characterization and gene cloning of 1,3-beta-D-glucan synthase from Saccharomyces cerevisiae.” Inoue S.B.et.al. 7649185 [4] “Identification of two cell cycle regulated genes affecting the beta 1,3-glucan content of cell walls in Saccharomyces cerevisiae.” Ram A.F.J.et.al. 7828729 [5] “Papulacandin B resistance in budding and fission yeasts: isolation and characterization of a gene involved in (1,3)beta-D-glucan synthesis in Saccharomyces cerevisiae.” Castro C.et.al. 7592316 [6] “Calcineurin, the Ca2+/calmodulin-dependent protein phosphatase, is essential in yeast mutants with cell integrity defects and in mutants that lack a functional vacuolar H(+)-ATPase.” Garrett-Engele P.et.al. 7542741 [7] “FKS1 mutations responsible for selective resistance of Saccharomyces cerevisiae to the novel 1,3-beta-glucan synthase inhibitor arborcandin C.” Ohyama T.et.al. 14693557 [8] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.” Johnston M.et.al. 9169871 [9] “Calcineurin-dependent growth of an FK506- and CsA-hypersensitive mutant of Saccharomyces cerevisiae.” Parent S.A.et.al. 7510323 [10] “Differential expression and function of two homologous subunits of yeast 1,3-beta-D-glucan synthase.” Mazur P.et.al. 7565718 [11] “In vitro activity of 1,3-beta-D-glucan synthase requires the GTP-binding protein Rho1.” Mazur P.et.al. 8662910 [12] “Identification of yeast Rho1p GTPase as a regulatory subunit of 1,3-beta-glucan synthase.” Qadota H.et.al. 8602515 [13] “Movement of yeast 1,3-beta-glucan synthase is essential for uniform cell wall synthesis.” Utsugi T.et.al. 11856368 [14] “Dissection of upstream regulatory components of the Rho1p effector, 1,3-beta-glucan synthase, in Saccharomyces cerevisiae.” Sekiya-Kawasaki M.et.al. 12399379 [15] “Mutations in Fks1p affect the cell wall content of beta-1,3- and beta-1,6-glucan in Saccharomyces cerevisiae.” Dijkgraaf G.J.P.et.al. 12185837 [16] “A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery.” Hitchcock A.L.et.al. 14557538 | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MNTDQQPYQG QTDYTQGPGN GQSQEQDYDQ YGQPLYPSQA DGYYDPNVAA GTEADMYGQQ 61: PPNESYDQDY TNGEYYGQPP NMAAQDGENF SDFSSYGPPG TPGYDSYGGQ YTASQMSYGE 121: PNSSGTSTPI YGNYDPNAIA MALPNEPYPA WTADSQSPVS IEQIEDIFID LTNRLGFQRD 181: SMRNMFDHFM VLLDSRSSRM SPDQALLSLH ADYIGGDTAN YKKWYFAAQL DMDDEIGFRN 241: MSLGKLSRKA RKAKKKNKKA MEEANPEDTE ETLNKIEGDN SLEAADFRWK AKMNQLSPLE 301: RVRHIALYLL CWGEANQVRF TAECLCFIYK CALDYLDSPL CQQRQEPMPE GDFLNRVITP 361: IYHFIRNQVY EIVDGRFVKR ERDHNKIVGY DDLNQLFWYP EGIAKIVLED GTKLIELPLE 421: ERYLRLGDVV WDDVFFKTYK ETRTWLHLVT NFNRIWVMHI SIFWMYFAYN SPTFYTHNYQ 481: QLVDNQPLAA YKWASCALGG TVASLIQIVA TLCEWSFVPR KWAGAQHLSR RFWFLCIIFG 541: INLGPIIFVF AYDKDTVYST AAHVVAAVMF FVAVATIIFF SIMPLGGLFT SYMKKSTRRY 601: VASQTFTAAF APLHGLDRWM SYLVWVTVFA AKYSESYYFL VLSLRDPIRI LSTTAMRCTG 661: EYWWGAVLCK VQPKIVLGLV IATDFILFFL DTYLWYIIVN TIFSVGKSFY LGISILTPWR 721: NIFTRLPKRI YSKILATTDM EIKYKPKVLI SQVWNAIIIS MYREHLLAID HVQKLLYHQV 781: PSEIEGKRTL RAPTFFVSQD DNNFETEFFP RDSEAERRIS FFAQSLSTPI PEPLPVDNMP 841: TFTVLTPHYA ERILLSLREI IREDDQFSRV TLLEYLKQLH PVEWECFVKD TKILAEETAA 901: YEGNENEAEK EDALKSQIDD LPFYCIGFKS AAPEYTLRTR IWASLRSQTL YRTISGFMNY 961: SRAIKLLYRV ENPEIVQMFG GNAEGLEREL EKMARRKFKF LVSMQRLAKF KPHELENAEF 1021: LLRAYPDLQI AYLDEEPPLT EGEEPRIYSA LIDGHCEILD NGRRRPKFRV QLSGNPILGD 1081: GKSDNQNHAL IFYRGEYIQL IDANQDNYLE ECLKIRSVLA EFEELNVEQV NPYAPGLRYE 1141: EQTTNHPVAI VGAREYIFSE NSGVLGDVAA GKEQTFGTLF ARTLSQIGGK LHYGHPDFIN 1201: ATFMTTRGGV SKAQKGLHLN EDIYAGMNAM LRGGRIKHCE YYQCGKGRDL GFGTILNFTT 1261: KIGAGMGEQM LSREYYYLGT QLPVDRFLTF YYAHPGFHLN NLFIQLSLQM FMLTLVNLSS 1321: LAHESIMCIY DRNKPKTDVL VPIGCYNFQP AVDWVRRYTL SIFIVFWIAF VPIVVQELIE 1381: RGLWKATQRF FCHLLSLSPM FEVFAGQIYS SALLSDLAIG GARYISTGRG FATSRIPFSI 1441: LYSRFAGSAI YMGARSMLML LFGTVAHWQA PLLWFWASLS SLIFAPFVFN PHQFAWEDFF 1501: LDYRDYIRWL SRGNNQYHRN SWIGYVRMSR ARITGFKRKL VGDESEKAAG DASRAHRTNL 1561: IMAEIIPCAI YAAGCFIAFT FINAQTGVKT TDDDRVNSVL RIIICTLAPI AVNLGVLFFC 1621: MGMSCCSGPL FGMCCKKTGS VMAGIAHGVA VIVHIAFFIV MWVLESFNFV RMLIGVVTCI 1681: QCQRLIFHCM TALMLTREFK NDHANTAFWT GKWYGKGMGY MAWTQPSREL TAKVIELSEF 1741: AADFVLGHVI LICQLPLIII PKIDKFHSIM LFWLKPSRQI RPPIYSLKQT RLRKRMVKKY 1801: CSLYFLVLAI FAGCIIGPAV ASAKIHKHIG DSLDGVVHNL FQPINTTNND TGSQMSTYQS 1861: HYYTHTPSLK TWSTIK