TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
9.B.12.1.1









Salt-stress and cold-shock-induced hydrophobic peptide, BLT101 or ESI3
Eukaryota
Viridiplantae
BLT101 of Lophopyrum elongatum (P68178)
9.B.12.1.2









Membrane peptide of 55 aas, plasma membrane proteolipid 3, Pmp3/Sna1. Plays a role in the regulation of membrane potential, possible by mediating a proton leak (Navarre and Goffeau 2000).

Eukaryota
Fungi
Pmp3p of Saccharomyces cerevisiae (P87284)
9.B.12.1.3









Pmp3 family (UPF0057) member of 87 aas.

Bacteria
Firmicutes
Pmp3 family member of Bacillus anthracis
9.B.12.1.4









Pmp3 famiy member of 56 aas

Bacteria
Firmicutes
Pmp3 family member of Bacillus subtilis
9.B.12.1.5









Ric1 of 58 aas

Bacteria
Bacteroidetes/Chlorobi group
Ric1 of Chlorobaculum parvum
9.B.12.1.6









hydrophobic peptide of 54 aas and 2 TMSs, RCI2A or LTI6A.  It is upregulated upon drought/salt stress (Kwok et al. 2020). It might oligomerized to form a proton channel but this hypothesis has not been tested.

Eukaryota
Viridiplantae
RCI2A of Arabidopsis thaliana (thale cress)
9.B.12.2.1









Uncharacterized ORF, YqaE, of 52 aas and 2 putative TMSs. The eukaryotic homologues functionally suppress the conditional growth defects in bacterial deletion mutant, demonstrating the conserved cross-kingdom membrane functions by PMP3(i)hs. There is a direct reciprocal relationship between PMP3(i)hs expression and Vm differentials in both prokaryotic and eukaryotic cells. Cumulative with the PMP3(i)hs ubiquitous abundance, their lipid-binding selectivities and membrane protein colocalization, it is a key element in membrane homeostasis (Kwok et al. 2020).

Bacteria
Proteobacteria
YqaE of E. coli (P0AE42)
9.B.12.2.2









Plasma membrane proteolipid 3, Pmp3 of 57 aas

Eukaryota
Fungi
Pmp3 of Rhizobus delemar
9.B.12.3.1









Uncharacterized ORF, Sna3 (YJL151c).  Targeting to the endosomal pathway depends on its interaction with Rsp5p, and multivesicular body sorting depends on ubiquitylation (Stawiecka-Mirota et al. 2007).

Eukaryota
Fungi
Sna3 of Saccharomyces cerevisiae
9.B.12.3.2









Vacuolar Sna4 of 140 aas with two N-terminal TMSs.  It is transported to the vauolar membrane via the alkaline phosphatase (ALP) pathway which bypasses the multivesicular bodies (MVBs) (Pokrzywa et al. 2009).

Eukaryota
Fungi
Sna4 of Saccharomyces cerevisiae
9.B.12.3.3









Sna2 of 79 aas.  Two tyroline-based sorting motifs are required for proper ER exit and vacuolar targeting (Renard et al. 2010).

Eukaryota
Fungi
Sna2 of Sacchaomyces cerevisiae
9.B.12.4.1









Uncharacterized ORF, F47B7.1
Eukaryota
Metazoa
F47B7.1 of Caenorhabditis elegans