TCDB is operated by the Saier Lab Bioinformatics Group

9.B.123 The Lysosomal 7-TMS (TM7SF1) Family

The TM7SF1 is a primarily lysosomal protein of 399aas in humans with 7 TMSs. It bears a dileucine-lysosomal targetting sequence and form putative N-glycosylation sites (Gao et al., 2012). Gao et al. (2012) suggest that it is a G-protein coupled receptor functioning in signal transduction across the lysosomal membrane. If so, it is very sequence divergent from the GPCR receptors in TC family 9.A.14. 

References associated with 9.B.123 family:

Gao J., Xia L., Lu M., Zhang B., Chen Y., Xu R. and Wang L. (2012). TM7SF1 (GPR137B): a novel lysosome integral membrane protein. Mol Biol Rep. 39(9):8883-9. 22729905
Patel, K.B., E. Toh, X.B. Fernandez, A. Hanuszkiewicz, G.G. Hardy, Y.V. Brun, M.A. Bernards, and M.A. Valvano. (2012). Functional characterization of UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferases of Escherichia coli and Caulobacter crescentus. J. Bacteriol. 194: 2646-2657. 22408159