TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
9.B.139.1.1









The cannibalism peptide toxin, SDP (SdpC) of 202 aas and 2 TMSs, N- and C-terminal.  It may be proteolytically processed to yield the active toxin which may function as a proton channel or carrier (Lamsa et al. 2012).

Bacteria
Bacillota
SdpC of Bacillus subtilis
9.B.139.1.2









SdpC homologue of 215 aas and 2 TMSs

Bacteria
Actinomycetota
SdpC of Streptomyces sp. Sirex AA-E
9.B.139.1.3









SdpC homologue of 223 aas and 2 TMSs

Bacteria
Actinomycetota
SdpC homologue in Tsukamurella paurometabola
9.B.139.1.4









SdpC homologue of 196 aas

Bacteria
Bacillota
SdpC homologue of Bacillus amyloliquefaciens
9.B.139.1.5









SdpC homologue of 206 aas

Bacteria
Bacillota
SdpC homologue of Bacillus thuringiensis
9.B.139.1.6









YitM of 194 aas and 2 or 3 TMSs in a 1 (N-terminal) + 1 or 2 TMS (C-terminal) arrangement.  The B.subtilis yitPOM operon is a paralog of the sdpABC operon, which produces the secreted peptide toxin SDP. Unlike sdpABC, yitPOM is induced in biofilms by the DegS-DegU two-component regulatory system. High yitPOM expression leads to the production of a secreted toxin called YIT. Expression of yitQ, which lies upstream of yitPOM, confers resistance to the YIT toxin, suggesting that YitQ is an anti-toxin protein for the YIT toxin. The alternative sigma factor SigW also contributes to YIT toxin resistance. In a mutant lacking yitQ and sigW, the YIT toxin specifically inhibits biofilm formation, and the extracellular neutral protease NprB is required for this inhibition (Kobayashi and Ikemoto 2019).

Bacteria
Bacillota
YIT (YitM) of Bacillus subtilis
9.B.139.2.1









SdpC homologue

Bacteria
Myxococcota
SdpC of Myxococcus xanthus
9.B.139.3.1









SdpC homologue of 231 aas.

Bacteria
Actinomycetota
SdpC homologue of Corynebacterium diphtheriae
9.B.139.3.2









SdpC homologue

Bacteria
Actinomycetota
SdpC homolgue of Corynebacterium pseudogenitalium