9.B.142.2.8
Polymyxin resistance protein of 448 aas and 13 TMSs, ArnT. ArnT catalyzes incorporation of 4-amino-4-deoxy-l-arabinose (l-Ara4N) into the lipid A
moiety of lipopolysaccharide (LPS) and is required for transport of LPS to the outer membrane (Tavares-Carreón et al. 2015). ArnT has a 13 TMS topology of key amino acids that contribute to its enzymatic function have been identified (Tavares-Carreón et al. 2015). In response to polymyxin exposure, differentially expressed genes in Acinetobacter baumannii have been identified (Li et al. 2020).
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| Accession Number: | V5BTU4 |
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| Protein Name: | Polymyxin resistance protein ArnT, undecaprenyl phosphate-alpha-L-Ara4N transferase |
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| Length: | 558 |
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| Molecular Weight: | 62632.00 |
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| Species: | Burkholderia cenocepacia KC-01 [1396830] |
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| Number of TMSs: | 13 |
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| Substrate |
lipopolysaccharide, 4-amino-4-deoxy-L-arabinose |
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1: MNDTPSRLPL NRITLVLLLV ALAIVWFAPL GLRHLIPSDE GRYAEMAREM FVTGDWITPR
61: YNGYKYFEKP PLQTWLNALT FAWFGIGEWQ ARLYTAVASF AGVLLVGYTG ARLFNPLSGF
121: LAAVVLASAP YWNLMGHFNA LDMGLAFWMA LSLCSLLLAQ RPGLRPAAVR GWMWACWAAM
181: AFAVLSKGLV GLILPGAVLV LYTLIARDWA LWKRLYLVSG LVIFFAIVTP WFVLVQQRNP
241: EFFDFFFIVQ QFRRYLTPEQ NRPGPLYYFV PVLLVGFLPW LSVAWQSIRH ALRMPRQPNG
301: FSPMLVLLIW SAFIFLFFSA SHSKLISYVL PVAPALALII GAYLPLMTAE RFRRHLLGYL
361: VFFVAAAFGI IFLAYQGDAR TPNALYRAFQ MWLYAGLAVS AALTLAAAWL NRRAGVAAAL
421: AAFGAAWLAF GTIGGTGHDE FGRYSSGALL APAVRAELAK LPPDTPFYSI EMLDHTFPFY
481: MGHTTIMVQR QDELAFGISV EPNKWVPTVG EWITRWKQDT HALAIMPPGQ YDALVKEGVP
541: MRVIARDNRR VIVEKPQS