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9.B.149.2.1
Regulator of σW transmembrane metaloprotease, RasP (YluC) of 422 aas and 4 - 6 TMSs. RasP, when defective, causes defects in competence development, protein secretion and membrane protein production (Zweers et al. 2012). σV activation in B. subtilis is controlled by regulated intramembrane proteolysis and requires RasP (Hastie et al. 2013). RasP also cleaves both of the stress response anti-sigma factors, RsiW and RsiV, as well as the cell division protein FtsL, and remnant signal peptides, within their transmembrane segments (Parrell et al. 2017).

Accession Number:O31754
Protein Name:Regulator of sigma-W protease RasP
Length:422
Molecular Weight:46744.00
Species:Bacillus subtilis (strain 168) [224308]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MFVNTVIAFI IIFGTLVFFH ELGHLLLAQR AGILCREFAI GFGPKIFSFK KNETVYTIRL 
61:	LPVGGFVRMA GEDPEMIEVK PGYTVGLLFN KEDQVEKVII NQKEKYPDAL VIEVETADLE 
121:	HDMKITGYEQ GKEDELSSFT VSETSFFIVD GEEVQIAPYN RQFGSKPVWQ RIKAIAAGPI 
181:	MNFILAYVIL VMLGLIQGVP SNEPMLGQLT DNGRAAEAGL KEGDYIQSIN GEKMRSWTDI 
241:	VSAVKENPEK EMDVAVKRDN KTLHISVTPE AVKDENKKTI GRFGSYAPTE KGVLSAVAYG 
301:	ATSTVDVTKA ILTNLSKLVT GQFKLDMLSG PVGIYDMTDQ VAKTGIVNLF QFAAFLSINL 
361:	GIVNLLPIPA LDGGRLLFLF IEAIRGKPIN REKEAFVVFI GVAFLMLLML VVTWNDIQRL 
421:	FL