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9.B.149.2.3
S2P integral membrane protease, RseP (Regulator of sigmaE protease) (YaeL or EcfE), of 450 aas and 5 TMSs in a 3 (N-terminal) + 2 (C-terminal) TMS arrangement (Kanehara et al. 2002; Alba et al. 2002). RseP regulates ferric citrate uptake by cleaving the sigma factor regulator, FecR (Yokoyama et al. 2021). It can also cleave sequences in transmembrane regions of other proteins (such as LacY) as well as liberated signal peptides of beta-lactamase, OmpF, LivK, SecM, PhoA, LivJ, OmpC, Lpp and TorA, probably within the membrane (Akiyama et al. 2004; Koide et al. 2008).

Accession Number:P0AEH1
Protein Name:Regulator of sigma-E protease RseP
Length:450
Molecular Weight:49071.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate

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FASTA formatted sequence
1:	MLSFLWDLAS FIVALGVLIT VHEFGHFWVA RRCGVRVERF SIGFGKALWR RTDKLGTEYV 
61:	IALIPLGGYV KMLDERAEPV VPELRHHAFN NKSVGQRAAI IAAGPVANFI FAIFAYWLVF 
121:	IIGVPGVRPV VGEIAANSIA AEAQIAPGTE LKAVDGIETP DWDAVRLQLV DKIGDESTTI 
181:	TVAPFGSDQR RDVKLDLRHW AFEPDKEDPV SSLGIRPRGP QIEPVLENVQ PNSAASKAGL 
241:	QAGDRIVKVD GQPLTQWVTF VMLVRDNPGK SLALEIERQG SPLSLTLIPE SKPGNGKAIG 
301:	FVGIEPKVIP LPDEYKVVRQ YGPFNAIVEA TDKTWQLMKL TVSMLGKLIT GDVKLNNLSG 
361:	PISIAKGAGM TAELGVVYYL PFLALISVNL GIINLFPLPV LDGGHLLFLA IEKIKGGPVS 
421:	ERVQDFCYRI GSILLVLLMG LALFNDFSRL