9.B.169 The Integral Membrane Protein (8 -10 TMSs) YeiB or DUF418 (YeiB) Family
The E. coli YeiB and B. subtilis YxaH proteins contain Pfam domains YeiB (the whole protein) and DUF418 (the C-terminal 4-5 TMS domain). This TC family includes proteins annotated as having DUF1624 and DUF5009 domains as well as DUF418. This family may be distantly related to TC family 9.B.97.
This family belongs to the: Transmembrane Acyl Transferease (TmAT) Superfamily.
References associated with 9.B.169 family:
Durand, S., M. Feldhammer, E. Bonneil, P. Thibault, and A.V. Pshezhetsky. (2010). Analysis of the biogenesis of heparan sulfate acetyl-CoA:α-glucosaminide N-acetyltransferase provides insights into the mechanism underlying its complete deficiency in mucopolysaccharidosis IIIC. J. Biol. Chem. 285: 31233-31242. 20650889
El Yacoubi, B., S. Bonnett, J.N. Anderson, M.A. Swairjo, D. Iwata-Reuyl, and V. de Crécy-Lagard. (2006). Discovery of a new prokaryotic type I GTP cyclohydrolase family. J. Biol. Chem. 281: 37586-37593. 17032654
Fan, X., H. Zhang, S. Zhang, R.D. Bagshaw, M.B. Tropak, J.W. Callahan, and D.J. Mahuran. (2006). Identification of the gene encoding the enzyme deficient in mucopolysaccharidosis IIIC (Sanfilippo disease type C). Am J Hum Genet 79: 738-744. 16960811
Hirooka, K. and Y. Fujita. (2011). Identification of aromatic residues critical to the DNA binding and ligand response of the Bacillus subtilis QdoR (YxaF) repressor antagonized by flavonoids. Biosci. Biotechnol. Biochem. 75: 1325-1334. 21737930