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9.B.17 The VAMP-associated protein (VAP) Family

The VAMP-associated proteins (VAPs) are highly conserved integral endoplasmic reticulum membrane proteins implicated in diverse cellular functions, including the regulation of lipid transport and homeostasis, membrane trafficking, neurotransmitter release, stabilization of presynaptic microtubules, and the unfolded protein response. Recently, a single missense mutation within the human VAP-B gene was identified in three forms of familial motor neuron disease. Yeast, flies and mammals have VAPs. There is a network of VAP-interacting proteins. Their mechanisms of action are not well understood (Lev et al., 2008). However, VAPs form a network with a reticulophagy receptor and Atg8 (Yang and Klionsky 2020).

References associated with 9.B.17 family:

Lev, S., D. Ben Halevy, D. Peretti, and N. Dahan. (2008). The VAP protein family: from cellular functions to motor neuron disease. Trends Cell Biol. 18: 282-290. 18468439
Yamanaka, T., R. Nishiyama, T. Shimogori, and N. Nukina. (2020). Proteomics-Based Approach Identifies Altered ER Domain Properties by ALS-Linked VAPB Mutation. Sci Rep 10: 7610. 32376919
Yang, Y. and D.J. Klionsky. (2020). A novel reticulophagy receptor, Epr1: a bridge between the phagophore protein Atg8 and ER transmembrane VAP proteins. Autophagy 1-2. [Epub: Ahead of Print] 33121335