9.B.187 The Two TMS Maurer's Cleft Protein (MC-2TM) Family
Plasmodium falciparum Maurer's clefts participate in the transport of macromolecules within the cytoplasm, including the transport of virulence proteins to the erythrocyte membrane surface. Tsarukyanova et al. 2009 identified a family of genes, PfMC-2TM, encoding transmembrane proteins located within the intramembranous network of the infected erythrocyte. They showed that PfMC-2TM is located in the Maurer's clefts throughout the intracellular blood stage, and domains of PfMC-2TM localized in the parasitophorous vacuole and parasitophorous vacuole membrane. The distribution of the 130 kDa Maurer's cleft protein changes from within the parasite to the clefts during intracellular development as the parasite matures from young trophozoite to segmented schizont (Tsarukyanova et al. 2009).
Warncke and Beck 2019 reviewed the molecular level of each host cell-remodeling step at each stage of the intraerythrocytic development of P. falciparum They described key events, such as invasion, knob formation, and egress, and identify the interactions between exported parasite proteins and the host cell cytoskeleton. Finally, they discussed each remodeling step with respect to time and specific requirements of the developing parasite to explain host cell remodeling in a stage-specific manner (Warncke and Beck 2019).