TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


9.B.191.1.5
KDEL receptor, KDELR of 212 aas and 7 TMSs.  Required for the retention of luminal endoplasmic reticulum resident proteins via vesicular recycling. This receptor recognizes the C-terminal K-D-E-L motif. COPI-coated transport intermediates, either in the form of round vesicles or as tubular processes, mediate retrograde traffic of the KDEL receptor-ligand complexes. Also required for normal vesicular traffic through the Golgi (Giannotta et al. 2015). Intra-Golgi transport as well as the known mechanisms for the retention of Golgi resident proteins and for the sorting and export of transmembrane cargo proteins have been reviewed (Lujan and Campelo 2021).  

Accession Number:P24390
Protein Name:ER lumen protein-retaining receptor 1
Length:212
Molecular Weight:24542.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cytoplasmic vesicle1 / Multi-pass membrane protein2
Substrate

Cross database links:

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MNLFRFLGDL SHLLAIILLL LKIWKSRSCA GISGKSQVLF AVVFTARYLD LFTNYISLYN 
61:	TCMKVVYIAC SFTTVWLIYS KFKATYDGNH DTFRVEFLVV PTAILAFLVN HDFTPLEILW 
121:	TFSIYLESVA ILPQLFMVSK TGEAETITSH YLFALGVYRT LYLFNWIWRY HFEGFFDLIA 
181:	IVAGLVQTVL YCDFFYLYIT KVLKGKKLSL PA