9.B.191.1.5 KDEL receptor, KDELR of 212 aas and 7 TMSs. Required for the retention of luminal
endoplasmic reticulum resident proteins via vesicular recycling. This
receptor recognizes the C-terminal K-D-E-L motif. COPI-coated transport
intermediates, either in the form of round vesicles or as tubular
processes, mediate retrograde traffic of the KDEL receptor-ligand
complexes. Also required for normal vesicular traffic through the Golgi (Giannotta et al. 2015). Intra-Golgi transport as well as the known mechanisms for the retention of Golgi resident proteins and for the sorting and export of transmembrane cargo proteins have been reviewed (Lujan and Campelo 2021).
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Accession Number: | P24390 |
Protein Name: | ER lumen protein-retaining receptor 1 |
Length: | 212 |
Molecular Weight: | 24542.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 7 |
Location1 / Topology2 / Orientation3: |
Cytoplasmic vesicle1 / Multi-pass membrane protein2 |
Substrate |
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1: MNLFRFLGDL SHLLAIILLL LKIWKSRSCA GISGKSQVLF AVVFTARYLD LFTNYISLYN
61: TCMKVVYIAC SFTTVWLIYS KFKATYDGNH DTFRVEFLVV PTAILAFLVN HDFTPLEILW
121: TFSIYLESVA ILPQLFMVSK TGEAETITSH YLFALGVYRT LYLFNWIWRY HFEGFFDLIA
181: IVAGLVQTVL YCDFFYLYIT KVLKGKKLSL PA