9.B.199 The 4 TMS PF05225 (PF0225) Family
The PF05225 family consists of uncharacterized 4 TMS proteins containing the conserved Pfam domain UPF0220 (Attwood et al. 2016). Some members of the family appear to be involved in vacuolar protein trafficking in yeast (Schluter et al. 2008). Additionally, targeted degradation of integral membrane proteins is ensured by a complex network of proteins, among which the endosomal sorting complex required for transport (ESCRT) plays a central role (Isono and Kalinowska 2017) (see 9.B.199.1.7).