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9.B.199 The 4 TMS PF05225 (PF0225) Family

The PF05225 family consists of uncharacterized 4 TMS proteins containing the conserved Pfam domain UPF0220 (Attwood et al. 2016).  Some members of the family appear to be involved in vacuolar protein trafficking in yeast (Schluter et al. 2008). Additionally, targeted degradation of integral membrane proteins is ensured by a complex network of proteins, among which the endosomal sorting complex required for transport (ESCRT) plays a central role (Isono and Kalinowska 2017) (see 9.B.199.1.7).

References associated with 9.B.199 family:

Attwood, M.M., A. Krishnan, V. Pivotti, S. Yazdi, M.S. Almén, and H.B. Schiöth. (2016). Topology based identification and comprehensive classification of four-transmembrane helix containing proteins (4TMs) in the human genome. BMC Genomics 17: 268. 27030248
Isono, E. and K. Kalinowska. (2017). ESCRT-dependent degradation of ubiquitylated plasma membrane proteins in plants. Curr. Opin. Plant Biol. 40: 49-55. [Epub: Ahead of Print] 28753460
Künzl, F., S. Früholz, F. Fäßler, B. Li, and P. Pimpl. (2016). Receptor-mediated sorting of soluble vacuolar proteins ends at the trans-Golgi network/early endosome. Nat Plants 2: 16017. 27249560
Schluter, C., K.K. Lam, J. Brumm, B.W. Wu, M. Saunders, T.H. Stevens, J. Bryan, and E. Conibear. (2008). Global analysis of yeast endosomal transport identifies the vps55/68 sorting complex. Mol. Biol. Cell 19: 1282-1294. 18216282