TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
9.B.2.1.1









CAAX protease2 of 302aas and 8 TMSs

Bacteria
Chlamydiae/Verrucomicrobia group
CAAX protease2 of Parachlamydia acanthamoebae (F8KZQ2)
9.B.2.1.2









CAAX protease2 of 258aas and 8 TMSs

Bacteria
Chlamydiae/Verrucomicrobia group
CAAX protease2 of Chlamydophila pecorum (F4DIL5)
9.B.2.1.3









CAAX protease2 of 256aas and 7 or 8 TMSs

Bacteria
Chlamydiae/Verrucomicrobia group
CAAX protease of Chlamydia trachomatis (Q3KMA8)
9.B.2.1.4









Uncharacterized protein of 420 aas

Archaea
Euryarchaeota
UP of Methanothermobacter thermautotrophicus
9.B.2.1.5









CAAX protease2 of 239aas and 5 or 6 TMSs

Bacteria
Bacteroidetes/Chlorobi group
CAAX protease2 of Porphyromonas catoniae (L1NER1)
9.B.2.1.6









Me2+-dependent protease of 303aas and 8 TMSs

Bacteria
Cyanobacteria
Protease of Acaryochloris marina (B0C1B4)
9.B.2.1.7









CAAX protease2 of 373aas and 11 TMSs

Archaea
Euryarchaeota
CAAX protease2 of Natronolimnobius innermongolicus (L9XEM0)
9.B.2.1.8









CAAX protease2 of 230aas and 6 TMSs

Bacteria
Firmicutes
CAAX protease2 of Sporosarcina newyorkensis (F9DWD5)
9.B.2.1.9









MceF CAAX Protease

Bacteria
Proteobacteria
MceF of Klebsiella pneumoniae
9.B.2.1.10









CAAX protease involved in immunity against bacteriocins (Pei and Grishin 2001).

Bacteria
Firmicutes
CAAX protease of Streptococcus pyogenes
9.B.2.1.11









CAAX protease of 233 aas.

Eukaryota
Cryptophyta
CAAX protease of Guillardia theta
9.B.2.1.12









Abortive infection domain protein, Abi of 193 aas.  The C-terminal region has the Abi domain.

Bacteria
Proteobacteria
Putative CAAX protease of Marinobacter aquaeolei (Marinobacter hydrocarbonoclasticus)
9.B.2.1.13









Abortive infection-like protein of 323 aas with a C-terminal Abi domain.

Eukaryota
Bangiophyceae
Abi protein of Galdieria sulphuraria
9.B.2.1.14









Abi domain-containing protein of 305 aas and 10 TMSs.

Bacteria
Fibrobacteres/Acidobacteria group
Abi protein of Koribacter versatilis
9.B.2.1.15









Abi domain-containing protein of 400 aas and 10 TMSs.

Eukaryota
Bangiophyceae
Abi protein of Galdieria sufphuraria
9.B.2.1.16









LsrS, a 229 aas CAAX peptidase that is required for receptor function for the killing activity of the lantibiiotics Smb and nisin (Biswas and Biswas 2014).  The peptidase activity is not required for receptor function.

Bacteria
Firmicutes
LsrS of Streptococcus mutans
9.B.2.1.17









CAAX protease of 223 aas and 7 TMSs

Eukaryota
Viridiplantae
CAAX protease of Chlamydomonas reinhardtii
9.B.2.1.18









Putative CAAX protease of 215 aas and 6 TMSs

Bacteria
Firmicutes
CAAX protease of Lactobacillus rhamnosus
9.B.2.1.19









Membrane peptidase, YdiL, of 293 aas.

Eukaryota
Viridiplantae
YdiL of Capsicum annuum
9.B.2.1.20









Intramembrane metaloprotease of 195 aas and 7 TMSs.

Bacteria
Firmicutes
Protease of Lactobacillus xiangfangensis
9.B.2.1.21









CPBP protease family member of 225 aas and 6 TMSs.

Bacteria
Firmicutes
Protease of Bacillus cereus
9.B.2.1.22









CPBP integral membrane metaloprotease family member of 242 aas and 6 TMSs.

Bacteria
Proteobacteria
Protease of Dokdonella koreensis
9.B.2.1.23









CAAX amino terminal protease family protein of 351 aas and 8 TMSs.

Bacteria
Firmicutes
CAAX protease of Clostridium methylpentosum
9.B.2.1.24









Uncharacterized putative integral membrane proteinof 240 aas and 6 TMSs.

Bacteria
Actinobacteria
UP of Mycobacterium tuberculosis
9.B.2.1.25









CAAX protease of 357 aas and 7 TMSs.

Archaea
Candidatus Lokiarchaeota
CAAX protease of Lokiarchaeum sp.
9.B.2.1.26









Uncharacterized putative peptidase of 163 aas and 5 putative TMSs.

Archaea
Candidatus Thorarchaeota
UP of Candidatus Thorarchaeota archaeon AB_25 (marine sediment metagenome)
9.B.2.1.27









Uncharacterized protein of 325 aas and 8 TMSs

Archaea
Candidatus Thorarchaeota
UP of Candidatus Thorarchaeota archaeon AB_25 (marine sedimet metagenome)
9.B.2.1.28









CPBP family intramembrane metalloprotease of 1141 aas and 7 TMSs, all at the C-terminus of the protein.

Bacteria
Actinobacteria
Protease of Bifidobacterium indicum
9.B.2.2.1









CAAX protease of 274 aas

Eukaryota
Bangiophyceae
CAAX protease of Galdieria sulphuraria
9.B.2.3.1









CAAX amino terminal protease of 306 aas and 8 TMSs.

Bacteria
Firmicutes
CAAX protease of Desulfitobacterium metallireducens
9.B.2.3.2









CAAX protease of 274 aas and 8 TMSs.

Bacteria
Chloroflexi
CAAX protease of Anaerolnea thermopila
9.B.2.4.1









Putative transporter of 206 aas and 6 TMSs.

Bacteria
Proteobacteria
Putative transporter of Klebsiella pneumoniae
9.B.2.4.2









Uncharacterized protein of 217 aas and 6 TMSs.

Bacteria
Proteobacteria
UP of Vibrio fischeri
9.B.2.4.3









Putative Brp/Blh family of β-carotene monooxygenases of 221 aas and 6 TMSs

Bacteria
Bacteroidetes/Chlorobi group
UP of Psychroflexus torquis
9.B.2.5.1









Uncharacterized protein of 230 aas and 6 TMSs

Bacteria
Proteobacteria
UP of Deftia acidovorans
9.B.2.5.2









Uncharacterized protein of 206 aas and 6 TMSs

Bacteria
Firmicutes
UP of Acidaminococcus intestini
9.B.2.5.3









Uncharacterized protein of 215 aas and 6 TMSs

Bacteria
Proteobacteria
UP of Salmonella schwarzengrund
9.B.2.5.4









Uncharacterized protein of 215 aas and 6 TMSs

Bacteria
Firmicutes
UP of Megamonas hypermegale
9.B.2.6.1









Uncharacterized protein of 209 aas and 5 or 6 TMSs

Bacteria
Proteobacteria
UP of Geobacter sp.
9.B.2.6.2









Uncharacterized protein of 181 aas and 5 putative TMSs. 

Bacteria
Proteobacteria
UP of an uncultured Desulfobacterium
9.B.2.6.3









Uncharacterized protein of 228 aas and 6 TMSs

Bacteria
Proteobacteria
UP of Parvibaculum lavamentivorans
9.B.2.6.4









Uncharacterized protein of 181 aas and 5 TMSs.

Bacteria
Proteobacteria
UP of Thioalkalimicrobium cyclicum
9.B.2.6.5









Uncharacterized protein of 228 aas and 7 TMSs

Bacteria
Proteobacteria
UP of Phyllobacterium sp. YR531
9.B.2.6.6









Uncharacterized protein of 172 aas and 5 TMSs.

Archaea
Euryarchaeota
UP of Methanococcus maripaludis
9.B.2.6.7









Uncharacterized protein of 227 aas and 6 TMSs

Bacteria
Proteobacteria
UP of Rhizobium sp.
9.B.2.7.1









Uncharacterized protein of 213 aas and 6 TMSs.  This protein is the only member of its subfamily, but a protein from Zymophilus raffinosivorans (gi# 518382944), not in UniProt as of 5/5/14, shows similarity to it as well as members of subfamily 9.B.2.5.

Bacteria
Proteobacteria
UP of Octadecabacter antarcticus
9.B.2.8.1









Putative CPBP family membrane metaloprotease of 195 aas and 7 TMSs.

Bacteria
Firmicutes
Protease of Streptococcus ferus
9.B.2.8.2









Putative membrane metaloprotease of 193 aas and 6 TMSs.

Bacteria
Candidatus Saccharibacteria
Protease of Candidatus Saccharibacteria bacterium
9.B.2.9.1









Uncharacterized protein of 329 aas and 6 TMSs in a 1 + 2 + 3 TMS arrangement

Archaea
Euryarchaeota
UP of Natronorubrum tibetense
9.B.2.10.1









The CPBP family intramembrane metalloprotease domain-containing protein of 468 aas and 7 TMSs.

Archaea
Euryarchaeota
CPBP protease of Methanomassiliicoccus luminyensis
9.B.2.10.2









Uncharacterized CPBP family intramembrane metalloprotease domain-containing protein of 366 aas and 8 TMSs.

Archaea
Euryarchaeota
UP of Aciduliprofundum boonei
9.B.2.10.3









Uncharacterized CPBP family intramembrane metalloprotease domain-containing protein of 369 aas and 7 TMSs.

Archaea
Euryarchaeota
UP of Candidatus Methanomethylophilus alvus
9.B.2.10.4









Uncharacterized CPBP family intramembrane metalloprotease domain-containing protein of 301 aas and 7 TMSs.

Archaea
Euryarchaeota
UP of methanogenic archaeon ISO4-H5
9.B.2.10.5









Uncharacterized CPBP family intramembrane metalloprotease domain-containing protein of 312 aas and 7 TMSs.

Archaea
Thaumarchaeota
UP of Candidatus Nitrosopelagicus brevis
9.B.2.11.1









CPBP family intramembrane metalloprotease of 213 aas

Bacteria
Proteobacteria
Protease of Pseudoalteromonas
9.B.2.11.2









CPBP/CAAX family intramembrane metaloprotease of 221 aas and 6 TMSs.

Bacteria
Proteobacteria
Metaloprotease of Microbulbifer aggregans
9.B.2.11.3









CAAX amino terminal protease self-immunity of 194 aas and 6 TMSs in a 2 + 2 + 2 arrangement.

Archaea
Candidatus Lokiarchaeota
CAAX protease of Lokiarchaeum sp. GC14_75 (marine sediment metagenome)
9.B.2.12.1









Uncharacterized protein of 207 aas and 6 TMSs

Bacteria
Candidatus Peregrinibacteria
UP of Candidatus Peribacter riflensis
9.B.2.12.2









Metaloprotease of 213 aas and 6 TMSs

Bacteria
Bacteroidetes
Metaloprotease of Lewinella cohaerens
9.B.2.13.1









Putative CAAX protease of 496 aas and 7 TMSs in a 1 (N-terminal) + 6 (C-terminal) TMS arrangement. The gene for this protein is adjacent to an ABC transporter (TC# 3.A.1.128.10), probably specific for a sporulation killing factor, SkfB (Grell et al. 2018). This protease may therefore function to process SkfB.

Bacteria
Firmicutes
Protease of Bacillus stratosphericus