9.B.203 The AIG1 Lipid Hydrolase (AIG1) Family
AIG1 and ADTRP are atypical hydrolytic enzymes that depend on conserved threonine and histidine residues for catalysis. Both AIG1 and ADTRP hydrolyze bioactive fatty acid esters of hydroxy fatty acids (FAHFAs) but not other major classes of lipids. Parsons et al. 2016 identified multiple cell-active, covalent inhibitors of AIG1 and showed that these agents block FAHFA hydrolysis in mammalian cells. AIG1 and ADTRP are members of an evolutionarily conserved class of transmembrane threonine hydrolases involved in bioactive lipid metabolism.