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9.B.204 The 4 TMS Ciliary Biogenesis TMEM17 (TMEM17) Family 

Mutations in TMEM17 cause defects in ciliogenesis (Li et al. 2016). TMEM17 proteins play a role in lung cancer (Zhang et al. 2017), prostate cancer (Takata et al. 2019) and breast cancer (Zhao et al. 2018). Most of these proteins have 4 or 5 TMSs.

References associated with 9.B.204 family:

Li, C., V.L. Jensen, K. Park, J. Kennedy, F.R. Garcia-Gonzalo, M. Romani, R. De Mori, A.L. Bruel, D. Gaillard, B. Doray, E. Lopez, J.B. Rivière, L. Faivre, C. Thauvin-Robinet, J.F. Reiter, O.E. Blacque, E.M. Valente, and M.R. Leroux. (2016). MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone. PLoS Biol 14: e1002416. 26982032
Liu, Y., S. Cao, M. Yu, and H. Hu. (2020). TMEM216 Deletion Causes Mislocalization of Cone Opsin and Rhodopsin and Photoreceptor Degeneration in Zebrafish. Invest Ophthalmol Vis Sci 61: 24. 32687549
Takata, R., A. Takahashi, M. Fujita, Y. Momozawa, E.J. Saunders, H. Yamada, K. Maejima, K. Nakano, Y. Nishida, A. Hishida, K. Matsuo, K. Wakai, T. Yamaji, N. Sawada, M. Iwasaki, S. Tsugane, M. Sasaki, A. Shimizu, K. Tanno, N. Minegishi, K. Suzuki, K. Matsuda, M. Kubo, J. Inazawa, S. Egawa, C.A. Haiman, O. Ogawa, W. Obara, Y. Kamatani, S. Akamatsu, and H. Nakagawa. (2019). 12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population. Nat Commun 10: 4422. 31562322
Zhang, X., Y. Zhang, Y. Miao, H. Zhou, G. Jiang, and E. Wang. (2017). TMEM17 depresses invasion and metastasis in lung cancer cells via ERK signaling pathway. Oncotarget 8: 70685-70694. 29050311
Zhao, Y., K. Song, Y. Zhang, H. Xu, X. Zhang, L. Wang, C. Fan, G. Jiang, and E. Wang. (2018). TMEM17 promotes malignant progression of breast cancer via AKT/GSK3β signaling. Cancer Manag Res 10: 2419-2428. 30122991