TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
9.B.204.1.1









TMEM17 of 198 aas and 4 TMSs.  Involved in the formation of cilia (Li et al. 2016).

Metazoa, Chordata
TMEM17 of Homo sapiens
9.B.204.1.2









Transmembrane protein 216, TMEM216 of 160 aas and 4 TMSs. TMEM216 deletion causes mislocalization of cone opsin and rhodopsin with photoreceptor degeneration in Zebrafish (Liu et al. 2020). Mutations in TMEM216, a ciliary transition zone tetraspan transmembrane protein, are linked to Joubert syndrome and Meckel syndrome, and photoreceptor degeneration is a prominent phenotype in Joubert syndrome. Homozygous tmem216 knockout zebrafish died before 21 days after fertilization. Their retina exhibited reduced immunoreactivity to rod photoreceptor outer segment marker 4D2 and cone photoreceptor outer segment marker G protein subunit alpha-transducin 2 (GNAT2). Thus, TMEM216 is essential for normal genesis of outer segment disc structures, transport of outer segment materials, and survival of photoreceptors in zebrafish (Liu et al. 2020)).

Eukaryota
Metazoa, Chordata
TMEM216 of Danio rerio (Zebrafish) (Brachydanio rerio)
9.B.204.1.3









Uncharacterized protein of 196 aas and 5 TMSs in a 1 + 4 TMS arrangement.

Eukaryota
Fungi, Chytridiomycota
UP of Batrachochytrium salamandrivorans
9.B.204.1.4









Uncharacterized protein of 195 aas and 5 TMSs in a 2 + 3 arrangement.

Eukaryota
Metazoa, Nematoda
UP of Litomosoides sigmodontis
9.B.204.1.5









Uncharacterized protein of 169 aas and 4 TMSs

Eukaryota
Euglenozoa
UP of Trypanosoma conorhini
9.B.204.1.6









Transmembrane protein of 173 aas and 4 TM

Eukaryota
Euglenozoa
TM protein of Strigomonas culicis
9.B.204.1.7









Uncharacterized protein of 209 aas and 4 TMSs

Eukaryota
Viridiplantae, Chlorophyta
UP of Micromonas pusilla
9.B.204.1.8









Uncharacterized protein of 160 aas and 4 TMSs.

Eukaryota
Euglenozoa
UP of Leishmania tarentolae
9.B.204.2.1









Exportin-6 protein of 1163 aas with 3 TMSs near the N-terminus plus several subsequent potential TMSs.

Eukaryota
Heterolobosea
Exportin-6 of Naegleria gruberi