TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
9.B.208.1.1









The Vitamin D3 Receptor, VDR of 427 aas and 0 - 1 TMS.  Possibly can insert into the plasma membrane and form a large channel (see family description) (Morrill et al. 2016).  It is a dimer with two transmembrane half helices (264K - N276) and 16 cholesterol binding (CRAC/CARC) domains.  May function with importin-4 (TC# 1.I.1.1.3) which may also be able to form a transmembrane channel (Morrill et al. 2016).

Eukaryota
Metazoa, Chordata
VDR of Homo sapiens
9.B.208.1.2









The bile acid farnesoid receptor of 472 or 486 aas but 0 TMSs. The farnesoid X receptor is an important target for the treatment of disorders of bile acid and fatty acid metabolism in mice with nonalcoholic fatty liver disease combined with cholestasis (Liu et al. 2023).

Eukaryota
Metazoa, Chordata
Farnesoid receptor of Homo sapiens
9.B.208.1.3









Nuclear receptor subfamily 1 group I member 2, or the pregnane X recpetor, of 434 aas and 0 TMSs.  It binds and is activated by a variety of endogenous and xenobiotic compounds and is a transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. It is activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones in a species-specific fashion. It is also activated by naturally occurring steroids, such as pregnenolone and progesterone (Lehmann et al. 1998; Geick et al. 2001; Watkins et al. 2003; Li et al. 2009).


Eukaryota
Metazoa, Chordata
Pregnane X recpetor of Homo sapiens
9.B.208.1.4









Nuclear receptor subfamily 5 group A member 2 of 541 aas.  It functions as a key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver and may also contribute to the regulation of pancreas-specific genes while playing important roles in embryonic development (Wang et al. 2005).

Metazoa, Chordata
9.B.208.1.5









Progesterone receptor, PGR, of 933 aas; it is a transcriptional regulatory protein responding to steroids such as progesterone.  It has various isoforms of differing functions; isoform 4 increases the mitochondrial membrane potential and cellular respiration upon stimulation by progesterone (Grimm et al. 2016).

Eukaryota
Metazoa, Chordata
PGR of Homo sapiens
9.B.208.1.6









Peroxisome proliferator-activated receptor alpha, PPARa or PPARα, of 468 aas. It is a ligand-activated transcription factor that is a key regulator of lipid metabolism.The expression of it structural gene is influenced by emodin (Cheng et al. 2021).

Eukaryota
Metazoa, Chordata
PPARα of Homo sapiens
9.B.208.1.7









Oxysterol receptor, LXR-allpha (LXRα) of 447 aas and 0 - 2 TMSs. The effect of liver X receptor agonist TO901317 on cognitive function in APP/PS1 double transgenic mice with Alzheimer's disease and the underlying mechanism have been determined (Luo et al. 2022).

Eukaryota
Metazoa, Chordata
LXRα of Homo sapiens