9.B.212 The Human Simplex Virus-1 gM protein (HSV-gM) Family
Envelope glycoprotein M (gM), of 473 aas and 8 TMSs in a 4 + 4 arrangement, is important for virion assembly and egress. It plays a role in the incorporation of the gH-gL protein complex into the virion membrane. It also directs the glycoprotein N (gN) to the host trans-Golgi network. All of the transmembrane domain is essential for function (Striebinger et al. 2015; Striebinger et al. 2016).