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9.B.212 The Human Simplex Virus-1 gM protein (HSV-gM) Family

Envelope glycoprotein M (gM), of 473 aas and 8 TMSs in a 4 + 4 arrangement, is important for virion assembly and egress. It plays a role in the incorporation of the gH-gL protein complex into the virion membrane. It also directs the glycoprotein N (gN) to the host trans-Golgi network.  All of the transmembrane domain is essential for function (Striebinger et al. 2015; Striebinger et al. 2016).

References associated with 9.B.212 family:

Striebinger, H., C. Funk, V. Raschbichler, and S.M. Bailer. (2016). Subcellular Trafficking and Functional Relationship of the HSV-1 Glycoproteins N and M. Viruses 8: 83. 26999189
Striebinger, H., J. Zhang, M. Ott, C. Funk, K. Radtke, J. Duron, Z. Ruzsics, J. Haas, R. Lippé, and S.M. Bailer. (2015). Subcellular trafficking and functional importance of herpes simplex virus type 1 glycoprotein M domains. J Gen Virol 96: 3313-3325. 26265177