TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
9.B.214.1.1









Erv29 of 310 aas and 4 (determined) to 7 (predicted) TMSs (Foley et al. 2007).

Eukaryota
Fungi, Ascomycota
Erv29 of Saccharomyces cerevisiae
9.B.214.1.2









Surfeit locus protein 4 of 269 aas and 8 predicted TMSs in a 4 + 4 TMS arrangement, Surf-4 or Surf4. It has amplification and increased expression in the tumor tissues of several human cancer patients. Overexpression of SURF4 leads to increased cell proliferation, migration, and maintenance of anchorage-independent growth. In addition, NIH3T3 cells overexpressing SURF4 induced tumor growth in mice (Kim et al. 2018). Surf-4, together with SAR1B (SARA2; SARB, of 198 aas and 0 TMSs; Q9Y6B6), ensures delivery of the packages to the cell membrane for secretion, and receptor-mediated ER export of lipoproteins controls lipid homeostasis in mice and humans (Wang et al. 2020). It functions as a cargo receptor, mediating cargo transport from the ER and the Golgi apparatus via the canonical coat protein complex II (COPII)-coated vesicles (Shen et al. 2022). It also participates in ER-Golgi protein trafficking through a tubular network and facilitates retrograde transport of cargos from the Golgi apparatus to the ER through COPI-coated vesicles (Shen et al. 2022). An overview of receptor-mediated transport of secretory proteins from the ER to the Golgi, with a focus on the current understanding of two mammalian cargo receptors: the LMAN1-MCFD2 complex and SURF4, has appeared (Zhang et al. 2023).

Eukaryota
Metazoa, Chordata
Surf-4 of Homo sapiens
9.B.214.1.3









ER-derived vesicles protein ERV29 of 292 aas and 8 TMSs in a 1 + 3 + 4 TMS arrangement. This protein may be distantly related to 2.A.7.43.

Eukaryota
Fungi, Ascomycota
ERV29 of Verticillium alfalfae
9.B.214.2.1









Uncharacterized protein of the DoxX family of 139 aas and 4 TMSs.

Bacteria
Cyanobacteriota
UP of Planktothrix tepida
9.B.214.2.2









DoxX family protein of 137 aas and 4 TMSs.

Bacteria
Pseudomonadota
DoxX homologue of Burkholderia ptereochthonis
9.B.214.2.3









DoxX/SURF4 family protein of 158 aas and 4 TMSs, YphA of unknown function.

Bacteria
Planctomycetota
DoxX of Rubinisphaera brasiliensis
9.B.214.2.4









Quinol oxidase of 145 aas and 4 TMSs. Uncharacterized membrane protein, YphA, of the DoxX/SURF4 family

Bacteria
Pseudomonadota
YphA of Burkholderia pseudomallei
9.B.214.2.5









DoxX family member of 158 aas and 4 TMSs

Bacteria
Candidatus Wolfebacteria
DoxX of Candidatus Wolfebacteria bacterium
9.B.214.2.6









DoxX of 141 aas and 4 TMSs. The superoxide-detoxifying enzyme (SodA), DoxX, and a predicted thiol-oxidoreductase (SseA) form a membrane-associated oxidoreductase complex (MRC) that physically links radical detoxification with cytosolic thiol homeostasis. Loss of any MRC component correlated with defective recycling of mycothiol and accumulation of cellular oxidative damage (Nambi et al. 2015).

Bacteria
Actinomycetota
DoxX of Mycobacterium tuberculosis
9.B.214.3.1









Protein of 541 aas and 6 TMSs with an N-terminal DoxX domain with 5 TMSs, and a C-terminal PHP (polymerase - histidinol-P - phosphatase) domain. 

Archaea
Candidatus Lokiarchaeota
DoxX - PHP domain protein of Lokiarchaeum sp. GC14_75
9.B.214.3.2









DoxX family proteinof 570 aas and 5 N-terminal TMSs within the DoxX domain.

Bacteria
Bacteroidota
DoxX family protein of Aequorivita soesokkakensis
9.B.214.3.3









DoxX domain protein of 138 aas and 4 TMSs

Bacteria
Bacillota
DoxX of Lysinibacillus sp.
9.B.214.4.1









DoxX family protein of 148 aas and  4 TMSs.

Bacteria
Pseudomonadota
DoxX of Hylemonella gracilis