TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
9.B.216.1.1









Mic60 (AIM28, FCJ1, FMP13) of 540 aas.  May be involved in vesicle-independent lipid transfer between organelles such as mitochondria, chloroplasts and the endoplasmic reticulum (Michaud et al. 2016).

Eukaryota
Fungi, Ascomycota
Mic60 of Saccharomyces cerevisiae
9.B.216.1.2









Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, Mic60 of 550 aas.
Eukaryota
Fungi, Ascomycota
Mic60 of Schizosaccharomyces pombe (Fission yeast)
9.B.216.1.3









Uncharacterized protein; Mic70 homologue; plays roles in the formation of contact sites to the outer membrane.

Eukaryota
Evosea
UP of Dictyostelium discoideum (Slime mold)
9.B.216.1.4









MICOS complex component, MIC60, of 758 aas and 1 N-terminal TMS. It is a determining factor for membrane curvature with the formation of cristae (Tarasenko et al. 2017).  Homologues of this protein are found in α-proteobacteria, the persumed evolutionary source of this mitochondrial protein (Alkhaja et al. 2012). It may catalyze transfer of lipids from the membranes of mitochondra to those of other organelles.  At the ultrastructural level, mutant mitochondria display loss of inner membrane organization. MINOS1/Mio10 in yeast is a constituent of Mitofilin/Fcj1 complexes in both human and yeast mitochondria (Alkhaja et al. 2012). In human mitochondria, the inner membrane MICOS complex interacts with the outer membrane sorting and assembly machinery (SAM) complex, to form the mitochondrial intermembrane space bridging complex (MIB) (Ott et al. 2015). May play a role in mitochondrial division (Cho et al. 2017).

Eukaryota
Metazoa, Chordata
MIC60 of Homo sapiens
9.B.216.1.5









MIC60 of 575 aas and one N-terminal TMS.

Eukaryota
Rhodophyta
MIC60 of Galdieria sulphuraria (Red alga)
9.B.216.1.6









Mic60, a MICOS compex subunit , of 650 aas and 1 TMSs.  The MICOS complex seems to mediate lipid transfer from the chloroplast to the mitochondrion via a non-vesicular lipid trafficking pathway at membrane contact sites (Jouhet et al. 2019).

Eukaryota
Viridiplantae, Streptophyta
Mic60 of Arabidopsis thaliana