9.B.217.1.4
PrsW transmembrane metaloprotease of 415 aas and 8 TMSs. PrsW regulates the activation of the ECF σ factor, CsfT and involved in the degradation of specific anti-sigma factors one of which is RsiT. It
controls the resistance of C. difficile to antimicrobial peptides that
are important for survival in the host (Ho and Ellermeier 2011).
|
| Accession Number: | Q188Z4 |
|---|
| Protein Name: | Protease PrsW |
|---|
| Length: | 238 |
|---|
| Molecular Weight: | 27827.00 |
|---|
| Species: | Peptoclostridium difficile (strain 630) [272563] |
|---|
| Number of TMSs: | 7 |
|---|
| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
|---|
| Substrate |
|
|---|
1: MKLDLFLLAI IPILIGMFWI RSKDRYCREP LIHLIKFFLI GAFLSVIIIL LENLLMKFNV
61: FEGYSELIYV SFVVAGLVEE GVKALILIPA LIKEKHFTEK LDGIIYSVFL ALGFATIENM
121: VYIFSESRNL ALQVGINRAV ISIPAHVMFA ITMGYYISKY KFEGNKNKRR EYLFMAVLIP
181: ILLHGVFDFI LMIEYRWAII LLIVYVIILW KINLDKLEKY MNHSKKVFFG NLRKKKKK