TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
9.B.217.1.1









The PrsW intramembrane metaloprotease of 218 aas and 5 - 7 TMSs in a 1 + 4  or 1-7 TMS arrangement (see family description).

Bacteria
Firmicutes
PrsW of Bacillus subtilis
9.B.217.1.2









Membrane-spanning metaloprotease , PrsS of 415 aas and 8 TMSs.  PrsS and σS function in a similar manner, and perhaps mediate virulence and resistance to DNA damage and cell wall-targeting antibiotics, via a common pathway (Krute et al. 2015).

Bacteria
Firmicutes
PrsS of Staphylococcus aureus
9.B.217.1.3









PrsW family intramembrane metalloprotease of 399 aas and 8 TMSs.

Bacteria
Actinobacteria
PrsW of Agromyces aureus
9.B.217.1.4









PrsW transmembrane metaloprotease of 415 aas and 8 TMSs.  PrsW regulates the activation of the ECF σ factor, CsfT and involved in the degradation of specific anti-sigma factors one of which is RsiT. It controls the resistance of C. difficile to antimicrobial peptides that are important for survival in the host (Ho and Ellermeier 2011).

Bacteria
Firmicutes
PrsW of Peptoclostridium difficile (Clostridium difficile)
9.B.217.1.5









PrsW family intramembrane metalloprotease of 234 aas and 7 TMSs.

Archaea
Euryarchaeota
PrsW of Thermococcus nautili
9.B.217.1.6









PsrW family protease of 344 aas and 8 TMSs.

Archaea
Euryarchaeota
PsrW of Haloarcula vallismortis
9.B.217.1.7









Uncharacterized PsrW family member of 757 aas and 13 TMSs.

PsrW homologue of Sporocytophaga myxococcoides
9.B.217.1.8









Uncharacterized membrane metaloprotease of 222 aas and 7 TMSs.

Bacteria
Candidatus Wolfebacteria
UP of Candidatus Wolfebacteria bacterium
9.B.217.2.1









Uncharacterized protein of 240 aas and 7 TMSs.

Archaea
Euryarchaeota
UP of Aciduliprofundum boonei
9.B.217.2.2









Uncharacterized protein of 233 aas

Archaea
Euryarchaeota
UP of Methanomassiliicoccus luminyensis
9.B.217.2.3









Uncharacterized Duf368 protein of 298 aas and 9 TMSs.

Bacteria
Firmicutes
UP of Peptoniphilus phoceensis
9.B.217.2.4









Uncharacterized protein of 239 aas and 7 TMSs.

Archaea
Euryarchaeota
UP of Candidatus Methanoplasma termitum